Phloretin
Encyclopedia
Phloretin is a dihydrochalcone
Dihydrochalcone
Dihydrochalcone is a chemical compound related to chalcone.Dihydrochalcones Dihydrochalcone (DHC) is a chemical compound related to chalcone.Dihydrochalcones Dihydrochalcone (DHC) is a chemical compound related to chalcone.Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′-trimethoxydihydrochalcone,...

, a type of natural phenols. It is the phloroglucin ester of paraoxyhydratropic acid. It can be found in apple tree leaves.

Metabolism

Phloretin hydrolase
Phloretin hydrolase
In enzymology, a phloretin hydrolase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are phloretin and H2O, whereas its two products are phloretate and phloroglucinol....

 uses phloretin and water to produce phloretate and phloroglucinol
Phloroglucinol
Phloroglucinol is a benzenetriol. It is an organic compound that is used in the synthesis of pharmaceuticals and explosives. This molecule exists in two forms, or tautomers, 1,3,5-trihydroxybenzene, which has phenol-like, and 1,3,5-cyclohexanetrione , which has ketone-like character. These two...

.

Glycosides

  • Phlorizin
    Phlorizin
    Phlorizin is a toxic 2'-glucoside of phloretin. It belongs to the group of dihydrochalcones, a type of flavonoids. It is a competitive inhibitor of renal glucose transport.Phlorizin is naturally occurring in some plants...

     is the 2'-glucoside
    Glucoside
    A glucoside is a glycoside that is derived from glucose. Glucosides are common in plants, but rare in animals. Glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes....

     of phloretin.
  • Naringin dihydrochalcone
    Naringin dihydrochalcone
    Naringin dihydrochalcone, sometimes abbreviated to naringin DC, is an artificial sweetener derived from naringin, a bitter compound found in citrus....

    is a diglycoside of phloretin.
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