Permissive temperature
Encyclopedia
The permissive temperature is the temperature at which a temperature sensitive mutant gene product takes on a normal, functional phenotype.
When a temperature sensitive mutant is grown in a permissive condition, the mutated
gene product behaves normally (meaning that the phenotype
isn't observed), even if there is a mutant allele
present. This results in the survival of the cell or organism, as if it were a wild type strain. In contrast, the nonpermissive temperature or restrictive temperature is the temperature at which the mutant phenotype is observed.
Most temperature sensitive mutations affect proteins, and are recessive and cause loss of protein function at the non-permissive temperature. The permissive temperature is one at which the protein typically can fold properly, or remain properly folded.
When a temperature sensitive mutant is grown in a permissive condition, the mutated
Mutant
In biology and especially genetics, a mutant is an individual, organism, or new genetic character, arising or resulting from an instance of mutation, which is a base-pair sequence change within the DNA of a gene or chromosome of an organism resulting in the creation of a new character or trait not...
gene product behaves normally (meaning that the phenotype
Phenotype
A phenotype is an organism's observable characteristics or traits: such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior...
isn't observed), even if there is a mutant allele
Allele
An allele is one of two or more forms of a gene or a genetic locus . "Allel" is an abbreviation of allelomorph. Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation...
present. This results in the survival of the cell or organism, as if it were a wild type strain. In contrast, the nonpermissive temperature or restrictive temperature is the temperature at which the mutant phenotype is observed.
Most temperature sensitive mutations affect proteins, and are recessive and cause loss of protein function at the non-permissive temperature. The permissive temperature is one at which the protein typically can fold properly, or remain properly folded.