Pepscan
Encyclopedia
Pepscan is a procedure for mapping and characterizing epitope
s involving the synthesis of overlapping peptide
s and analysis of the peptides in enzyme-linked immunosorbent assays (ELISAs). The method is based on combinatorial chemistry
and was pioneered by Mario Geysen and coworkers .
Epitope mapping
Epitope mapping is the process of identifying the binding sites, or ‘epitopes’, of antibodies on their target antigens .Identification and characterization of the binding sites of antibodies can aid in the discovery and development of new therapeutics, vaccines, and diagnostics.Epitopes can be...
s involving the synthesis of overlapping peptide
Peptide
Peptides are short polymers of amino acid monomers linked by peptide bonds. They are distinguished from proteins on the basis of size, typically containing less than 50 monomer units. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond...
s and analysis of the peptides in enzyme-linked immunosorbent assays (ELISAs). The method is based on combinatorial chemistry
Combinatorial chemistry
Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules or materials...
and was pioneered by Mario Geysen and coworkers .