PepT 1
Encyclopedia
Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein
that in humans is encoded by SLC15A1 gene
. PepT 1 is a solute carrier for oligopeptide
s. It functions in renal oligopeptide reabsorption
and in the intestines in a proton dependent way, hence acting like a cotransporter.
membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen
into the enterocyte
s. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by SLC15A1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. PepT 1 is a solute carrier for oligopeptide
Oligopeptide
An oligopeptide consists of between 2 and 20 amino acids and includes dipeptides, tripeptides, tetrapeptides, pentapeptides, etc.Examples of oligopeptides include:...
s. It functions in renal oligopeptide reabsorption
Renal oligopeptide reabsorption
Renal oligopeptide reabsorption is the part of renal physiology that deals with the retrieval of filtered oligopeptides, preventing them from disappearing from the body through the urine....
and in the intestines in a proton dependent way, hence acting like a cotransporter.
Function
SLC15A1is localized to the brush borderBrush border
A brush border is the name for the microvilli-covered surface of simple cuboidal epithelium and simple columnar epithelium cells found in certain locations of the body. Microvilli are approximately 100 nanometers in diameter and their length varies from approximately 100 to 2,000 nanometers in...
membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen
Lumen (anatomy)
A lumen in biology is the inside space of a tubular structure, such as an artery or intestine...
into the enterocyte
Enterocyte
Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal...
s. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.