Paul Terasaki
Encyclopedia
Paul Ichiro Terasaki is a noted scientist in the field of human organ transplant
technology and Professor Emeritus of Surgery
at UCLA School of Medicine.
He spent three high school
years during World War II
interned with his family and other Japanese Americans in the Gila River War Relocation Center
. Later he earned his doctorate
in zoology
at UCLA and was appointed to the medical school
faculty.
In 1964, Terasaki developed the microcytotoxicity test, a tissue-typing test for organ transplant donors and recipients that required only 1 microliter each of antisera used to identify human leukocyte antigen
s (HLA). The test was adopted as the international standard
for tissue typing
. He has focused on study of the humoral theory of transplant rejection
, which states that antibodies cause allograft rejection. He and his corporation, One Lambda, have played a central role in the development of tissue typing and transplantation surgery.
Terasaki established UCLA's HLA laboratory, and also established the UCLA Kidney Transplant Registry, the largest in the world. In 1999, he retired from UCLA, but within a year resumed his academic pursuits with the creation of the Terasaki Foundation, a research center dedicated to cancer immunotherapy and the study of humoral immunity and transplantation.
On May 13, 2010, UCLA announced the naming of the new life science building for Terasaki, who has given $50 million to the Division of Life Sciences in the UCLA College of Letters and Science
, which is the largest ever given to the UCLA College. The structure will be known as the Terasaki Life Sciences Building.
Paul Terasaki is married to artist
Hisako Terasaki
; they have four children.
Organ transplant
Organ transplantation is the moving of an organ from one body to another or from a donor site on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative medicine is allowing scientists and engineers to create organs to be...
technology and Professor Emeritus of Surgery
Surgery
Surgery is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, or to help improve bodily function or appearance.An act of performing surgery may be called a surgical...
at UCLA School of Medicine.
He spent three high school
High school
High school is a term used in parts of the English speaking world to describe institutions which provide all or part of secondary education. The term is often incorporated into the name of such institutions....
years during World War II
World War II
World War II, or the Second World War , was a global conflict lasting from 1939 to 1945, involving most of the world's nations—including all of the great powers—eventually forming two opposing military alliances: the Allies and the Axis...
interned with his family and other Japanese Americans in the Gila River War Relocation Center
Gila River War Relocation Center
The Gila River War Relocation Center was an internment camp built by the War Relocation Authority for internment of Japanese Americans during the Second World War. It was located about southeast of Phoenix, Arizona....
. Later he earned his doctorate
Doctorate
A doctorate is an academic degree or professional degree that in most countries refers to a class of degrees which qualify the holder to teach in a specific field, A doctorate is an academic degree or professional degree that in most countries refers to a class of degrees which qualify the holder...
in zoology
Zoology
Zoology |zoölogy]]), is the branch of biology that relates to the animal kingdom, including the structure, embryology, evolution, classification, habits, and distribution of all animals, both living and extinct...
at UCLA and was appointed to the medical school
Medical school
A medical school is a tertiary educational institution—or part of such an institution—that teaches medicine. Degree programs offered at medical schools often include Doctor of Osteopathic Medicine, Bachelor/Doctor of Medicine, Doctor of Philosophy, master's degree, or other post-secondary...
faculty.
In 1964, Terasaki developed the microcytotoxicity test, a tissue-typing test for organ transplant donors and recipients that required only 1 microliter each of antisera used to identify human leukocyte antigen
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
s (HLA). The test was adopted as the international standard
International standard
International standards are standards developed by international standards organizations. International standards are available for consideration and use, worldwide...
for tissue typing
Tissue typing
Tissue typing is a procedure in which the tissues of a prospective donor and recipient are tested for compatibility prior to transplantation. An embryo can be tissue typed to ensure that the embryo implanted can be a cord-blood stem cell donor for a sick sibling.One technique of tissue typing,...
. He has focused on study of the humoral theory of transplant rejection
Transplant rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after...
, which states that antibodies cause allograft rejection. He and his corporation, One Lambda, have played a central role in the development of tissue typing and transplantation surgery.
Terasaki established UCLA's HLA laboratory, and also established the UCLA Kidney Transplant Registry, the largest in the world. In 1999, he retired from UCLA, but within a year resumed his academic pursuits with the creation of the Terasaki Foundation, a research center dedicated to cancer immunotherapy and the study of humoral immunity and transplantation.
On May 13, 2010, UCLA announced the naming of the new life science building for Terasaki, who has given $50 million to the Division of Life Sciences in the UCLA College of Letters and Science
UCLA College of Letters and Science
The College of Letters and Science is the arts and sciences college of the University of California, Los Angeles . It encompasses the Life and Physical Sciences, Humanities, Social Sciences, Honors Program and other programs for both undergraduate and graduate students.The bulk of UCLA's student...
, which is the largest ever given to the UCLA College. The structure will be known as the Terasaki Life Sciences Building.
Paul Terasaki is married to artist
Artist
An artist is a person engaged in one or more of any of a broad spectrum of activities related to creating art, practicing the arts and/or demonstrating an art. The common usage in both everyday speech and academic discourse is a practitioner in the visual arts only...
Hisako Terasaki
Hisako Terasaki
Hisako Terasaki , is a Japanese American etcher.-Early years:Terasaki's parents were economic migrants from Japan to the United States at the turn of the twentieth century...
; they have four children.
Publications
- Terasaki PI, McClelland JD. Microdroplet assay of human serum cytotoxins. Nature 1964; 204: 998–1000.
- Terasaki PI. Resolution by HLA testing of 1000 paternity cases not excluded by ABO testing. J Family Law 1977; 16: 543–557.
- Scholsstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HLA antigen, w27, with ankylosing spondylitis. N Engl J Med 1973; 228: 704–706.
- Collins GM, Bravo-Shugarman M, Terasaki PI. Kidney preservation for transportation. Initial perfusion and 30 hour ice storage. Lancet 1969; ii: 1219.
- Takemoto SK, Terasaki PI, Gjertson DW, Cecka JM. Twelve years’ experience with national sharing of HLA matched cadaveric kidneys for transplantation. New Engl J Med 2000; 343: 1078–1084.
- Terasaki PI, Marchioro TL, Starzl TE. Serotyping of human lymphocyte antigens. Preliminary trials on long-term kidney homograft survivors. Nat Acad Sci Monograph 1965; 83–96.
- Terasaki PI, ed. History of HLA. Ten Recollections. Los Angeles: UCLA Tissue Typing Laboratory; 1990.
- Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969; 280: 735–739.
- Nishikawa K, Terasaki PI. Annual trends and triple therapy – 1991–2000. In: Cecka, JM, Terasaki, PI, eds. Clinical Transplants 2001. Los Angeles: UCLA Immunogenetics Center; 2002, pp. 247–270.
- Terasaki PI. Red cell crossmatching for heart transplants (letter). N Engl J Med 1991; 325: 1748.
- Mickey MR, Kreisler M, Albert ED, Tanaka N, Terasaki PI. Analysis of HLA incompatibility in human renal transplants. Tissue Antigens 1971; 2: 57–67.
- Terasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995; 333: 333–336.
- Terasaki PI, Mickey MR, Kreisler M. Presensitization and kidney transplant failures. Postgrad Med 1970; 47: 89–100.
- Opelz G, Sengar DPS, Mickey MR, Terasaki PI. Effect of blood transfusions on subsequent kidney transplants. Transplant Proc 1973; 4: 253–259.
- Terasaki PI, Cho YW, Cecka JM. Editorial: Strategy for eliminating the kidney shortage. In: Cecka, M, Terasaki, PI, eds. Clinical Transplants 1997. Los Angeles: UCLA Tissue Typing Laboratory; 1998, pp. 265–267.
- Mckenna RM, Takemoto SK, Terasaki PI. Anti-HLA antibodies after solid organ transplantation. Transplantation 2000; 69:319–326.
- Lee PC, Terasaki PI, Takemoto SK et al. All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Transplantation 2002; 74: 1192–1194.
- Terasaki PI. Antibody response to homografts. I. Preliminary studies of the time of appearance of lymphoagglutinins upon homografting. Am Surg 1959; 11: 896–899.
- Terasaki PI. The humoral theory of transplantation. Am J Transpl 2003; 3: 665–673.
- Cho YW, Terasaki PI, Cecka JM, Gjertson DW. Transplantation of kidneys from donors whose heart has stopped beating. N Engl J Med 1998; 338: 221–225.