Paul III and His Nephews Alessandro and Ottavio Farnese
Overview
 
Pope Paul III and his Grandsons was painted by the Italian Renaissance
Italian Renaissance
The Italian Renaissance began the opening phase of the Renaissance, a period of great cultural change and achievement in Europe that spanned the period from the end of the 13th century to about 1600, marking the transition between Medieval and Early Modern Europe...

 artist Titian
Titian
Tiziano Vecelli or Tiziano Vecellio Tiziano Vecelli or Tiziano Vecellio Tiziano Vecelli or Tiziano Vecellio (c. 1488/1490 – 27 August 1576 better known as Titian was an Italian painter, the most important member of the 16th-century Venetian school. He was born in Pieve di Cadore, near...

 between 1545-1546 on oil and canvas. The painting portrays the aged Pope Paul III sitting, with his grandson Ottavio Farnese, Duke of Parma
Ottavio Farnese, Duke of Parma
Ottavio Farnese reigned as Duke of Parma and Piacenza from 1547 and Duke of Castro from 1545 until his death.-Biography:...

 kneeling at his left, and, behind him on the right, his other grandson Alessandro donning the cardinal dress.
The Italian title of the painting can be translated as "Pope Paul III and his Nephews", but they weren't nephews in a biological sense.
 
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