P antigen system
Encyclopedia
P antigen system is a human blood group system
based upon genes on chromosome 22. The P antigens are carbohydrate antigens that include P1, P, and Pk. The P antigen is a receptor
for the human pathogen Parvovirus B19
and is the target of auto-anti-P IgG antibodies in paroxysmal cold hemoglobinuria
.
Human blood group systems
The International Society of Blood Transfusion currently recognises 30 major blood group systems . Thus, in addition to the ABO antigens and Rhesus antigens, many other antigens are expressed on the red blood cell surface membrane...
based upon genes on chromosome 22. The P antigens are carbohydrate antigens that include P1, P, and Pk. The P antigen is a receptor
Immune receptor
An immune receptor is a receptor, usually on a cell membrane, which binds to a substance and causes a response in the immune system.-Types:...
for the human pathogen Parvovirus B19
Parvovirus B19
The B19 virus, generally referred to as parvovirus B19 or sometimes erythrovirus B19, was the first known human virus in the family of parvoviruses, genus erythrovirus...
and is the target of auto-anti-P IgG antibodies in paroxysmal cold hemoglobinuria
Paroxysmal cold hemoglobinuria
Paroxysmal cold hemoglobinuria is a disease of humans that is characterized by the sudden presence of hemoglobin in the urine , typically after exposure to cold temperatures....
.
External links
- P at BGMUTBGMUTThe BGMUT Database documents allelic variations in the genes encoding for human blood group systems. It was set up in 1999 through an initiative of the Human Genome Variation Society . Since 2006, it has been a part of the dbRBC resource of NCBI at the NIH...
Blood Group Antigen Gene Mutation Database at NCBINational Center for Biotechnology InformationThe National Center for Biotechnology Information is part of the United States National Library of Medicine , a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988 through legislation sponsored by Senator Claude Pepper...
, NIH