PPP2R1A
Encyclopedia
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme
that in humans is encoded by the PPP2R1A gene
. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).
. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.
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Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the PPP2R1A gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).
Function
This gene encodes a constant regulatory subunit of protein phosphatase 2Protein Phosphatase 2
Protein phosphatase 2 , also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase, is a ubiquitous and conserved Serine/Threonine phosphatase with broad substrate specificity and diverse cellular functions...
. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.
Interactions
PPP2R1A has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
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- CTTNBP2NLCTTNBP2NLCTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the CTTNBP2NL gene.-Interactions:CTTNBP2NL has been shown to interact with RP6-213H19.1, STRN, PDCD10, STRN3, PPP2R1A, MOBKL3, STK24, FAM40A and PPP2CA.-Further reading:...
, - FAM40AFAM40AProtein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the FAM40A gene.-Characteristics and secondary structure:...
, - PPP2CBPPP2CBSerine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.-Interactions:PPP2CB has been shown to interact with TLX1, PPP2R1B and PPP2R1A.-Further reading:...
, PPP2CAPPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that in humans is encoded by the PPP2CA gene.-Interactions:...
, PPP4CPPP4CSerine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.-Interactions:PPP4C has been shown to interact with CCT2, CCT4, CCT7, SMEK2, CCT6A, CCT3, IGBP1, PPP4R1, CCT5, T-complex 1, REL, CCDC6, TRAF6 and PPP2R1A.-Further reading:...
, - PPP2R2APPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme that in humans is encoded by the PPP2R2A gene.-Interactions:...
, - PPP2R3BPPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.-Interactions:PPP2R3B has been shown to interact with PPP2R1B, PPP2R1A, CDC6 and PPP2CA.-Further reading:...
, - PPP2R5APPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.-Interactions:PPP2R5A has been shown to interact with PPP2R1B, PPP2R1A, CTLA-4, AXIN1 and PPP2CA....
. - STK24STK24Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene.-Interactions:STK24 has been shown to interact with PDCD10, TRAF3IP3, STRN3, MOBKL3, STRN, SLMAP, PPP2R1A, CTTNBP2NL, FAM40A and STRN4.-Further reading:...
, - STRNSTRNStriatin is a protein that in humans is encoded by the STRN gene.-Interactions:STRN has been shown to interact with STK25, PDCD10, CTTNBP2, TRAF3IP3, STRN3, MOBKL3, STK24, PPP2CA, RP6-213H19.1, PPP2R1A, CTTNBP2NL and FAM40A.-Further reading:...
, and - STRN3STRN3Striatin-3 is a protein that in humans is encoded by the STRN3 gene.-Interactions:STRN3 has been shown to interact with PDCD10, CTTNBP2, MOBKL3, STK24, PPP2CA, RP6-213H19.1, STRN, PPP2R1A, CTTNBP2NL and FAM40A.-Further reading:...
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