PP2 (kinase inhibitor)
Encyclopedia
PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinases. It strongly inhibits the kinases Lck
(IC50
=4 nM), Fyn
(5 nM) and Hck
(5 nM), shows weaker inhibition of EGFR
(480 nM) and practically no inhibition of ZAP-70
(100 µM) and JAK2 (50 µM).
Lck
Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes...
(IC50
IC50
The half maximal inhibitory concentration is a measure of the effectiveness of a compound in inhibiting biological or biochemical function. This quantitative measure indicates how much of a particular drug or other substance is needed to inhibit a given biological process by half...
=4 nM), Fyn
FYN
Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth...
(5 nM) and Hck
HCK
Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.-Interactions:HCK has been shown to interact with BCR gene, ELMO1, Cbl gene, RAS p21 protein activator 1, RASA3, Granulocyte colony-stimulating factor receptor, ADAM15 and RAPGEF1.-Further reading:...
(5 nM), shows weaker inhibition of EGFR
Epidermal growth factor receptor
The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands...
(480 nM) and practically no inhibition of ZAP-70
ZAP-70
ZAP-70 is an abbreviation for Zeta-chain-associated protein kinase 70 . The protein is a member in the protein-tyrosine kinase family...
(100 µM) and JAK2 (50 µM).