PLAT domain
Encyclopedia
PLAT domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase
Lipoxygenase
Lipoxygenases are a family of iron-containing enzymes that catalyse the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene structure. It catalyses the following reaction:...

, Alpha-Toxin
Clostridium perfringens alpha toxin
Clostridium perfringens alpha toxin is a toxin produced by the bacterium Clostridium perfringens and is responsible for gas gangrene and myonecrosis in infected tissues. The toxin also possesses hemolytic activity....

) domain name="PUB00018111"> or LH2 (Lipoxygenase homology) domain. The known structure
of pancreatic lipase shows this domain binds to procolipase , which mediates membrane association.

This domain is found in a variety of membrane or lipid associated proteins. It forms a beta-sandwich composed of two sheets of four strands each.

Human proteins containing this domain

ALOX12
ALOX12
Arachidonate 12-lipoxygenase, 12S-type is an enzyme that in humans is encoded by the ALOX12 gene.-Interactions:ALOX12 has been shown to interact with Keratin 5 and LMNA.-Further reading:...

; ALOX12B
ALOX12B
Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, is an enzyme which in humans is encoded by the ALOX12B gene.-Function:This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid....

; ALOX12P2; ALOX15
ALOX15
Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene.-Further reading:...

; ALOX15B
ALOX15B
Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.-Further reading:...

; ALOX5; ALOXE3
ALOXE3
Epidermis-type lipoxygenase 3 is an enzyme that in humans is encoded by the ALOXE3 gene.-Further reading:...

; LIPC
Hepatic lipase
Hepatic lipase is a form of lipase. It is expressed in the liver and adrenal glands.One of the principal functions of hepatic lipase is to convert IDL to LDL.-Clinical significance:...

;
LIPG; LOXHD1; LPL
LPL
- Organizations :* Speech and language laboratory , a CNRS research center for speech and language research* LG.Philips LCD, the former name of the South Korean company LG Display...

; PKD1
PKD1
Polycystin-1 is a protein that in humans is encoded by the PKD1 gene.-Gene product:-Function:Polycystin-1 is a glycoprotein which contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail...

; PKD1L1; PKD1L2; PKD1L3; PKDREJ;
PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;
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