Oxidoreductase NAD-binding domain
Encyclopedia
Oxidoreductase NAD-binding domain is an evolutionary conserved protein domain
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Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.
Bacterial ferredoxin-NADP+ reductase may be bound to the thylakoid membrane or anchored to the thylakoid-bound phycobilisomes. Chloroplast ferredoxin-NADP+ reductase may play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power. It is involved in the final step in the linear photosynthetic electron transport chain and has also been implicated in cyclic electron flow around photosystem I where its role would be to return electrons from ferredoxin to the cytochrome B-F complex.
This domain is present in a variety of proteins that include, bacterial flavohemoprotein, mammalian NADH-cytochrome b5 reductase, eukaryotic NADPH-cytochrome P450 reductase, nitrate reductase from plants, nitric-oxide synthase, bacterial vanillate demethylase and others.
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
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Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.
Bacterial ferredoxin-NADP+ reductase may be bound to the thylakoid membrane or anchored to the thylakoid-bound phycobilisomes. Chloroplast ferredoxin-NADP+ reductase may play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power. It is involved in the final step in the linear photosynthetic electron transport chain and has also been implicated in cyclic electron flow around photosystem I where its role would be to return electrons from ferredoxin to the cytochrome B-F complex.
This domain is present in a variety of proteins that include, bacterial flavohemoprotein, mammalian NADH-cytochrome b5 reductase, eukaryotic NADPH-cytochrome P450 reductase, nitrate reductase from plants, nitric-oxide synthase, bacterial vanillate demethylase and others.
Examples
Human genes encoding proteins containing this domain include:- CYB5R1CYB5R1NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene.-Further reading:...
; CYB5R2CYB5R2Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene....
; CYB5R4CYB5R4Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.-Further reading:...
; MTRRMTRR (gene)Methionine synthase reductase, mitochondrial also known as MSR is an enzyme that in humans is encoded by the MTRR gene.- Function :...
; - NDOR1NDOR1NADPH-dependent diflavin oxidoreductase 1 is an enzyme that in humans is encoded by the NDOR1 gene.-Further reading:...
; NOS1NOS1Nitric oxide synthase 1 , also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.- Function :Nitric oxide is a messenger molecule with diverse functions throughout the body...
; NOS2A; NOS3Endothelial NOSEndothelial NOS , also known as nitric oxide synthase 3 or constitutive NOS , is an enzyme that in humans is encoded by the NOS3 gene....
; - OXNAD1; PORCytochrome P450 reductaseCytochrome P450 reductase is a membrane-bound enzyme required for electron transfer to cytochrome P450 in the microsome of the eukaryotic cell from a FAD- and FMN-containing enzyme NADPH:cytochrome P450 reductase .-Introduction:...
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