Oxidoreductase FAD-binding domain
Encyclopedia
The oxidoreductase FAD-binding domain is an evolutionary conserved protein domain
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To date, the 3D-structures of the flavoprotein domain of Zea mays nitrate reductase and of pig NADH:cytochrome b5 reductase have been solved. The overall fold is similar to that of ferredoxin:NADP+ reductase: the FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet flanked by 2 helices on each side).
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
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To date, the 3D-structures of the flavoprotein domain of Zea mays nitrate reductase and of pig NADH:cytochrome b5 reductase have been solved. The overall fold is similar to that of ferredoxin:NADP+ reductase: the FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet flanked by 2 helices on each side).
Examples
Human genes encoding proteins containing this domain inlclude:- CYB5R1CYB5R1NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene.-Further reading:...
; CYB5R2CYB5R2Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene....
; CYB5R4CYB5R4Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.-Further reading:...
; CYB5RL;