Oxantel
Encyclopedia
Oxantel is an anthelmintic
. It has typically been used human and animal use as a standard treatment for intestinal worms.
Oxantel is currently being experimented with for the treatment of periodontal disease by the Cooperative Research Centre for Oral Health Science (CRC). Professor Eric Reynolds (also the head of Dental School at the University of Melbourne, Australia) and his Associate Professor Stuart Dashper are currently testing its ability as a Fumarate reductase
inhibitor.
Fumarate reductase
is an enzyme that has been found in the pathogenic bacteria in the biofilm in periodontal pockets. This bacteria has the ability to convert blood components into energy and for the bacteria to be virulent. Such bacteria would starve without this enzyme. As such, the role of the Oxantel as a fumarate reductase inhibitor would be to kill the bacteria responsible for periodontal disease.
Anthelmintic
Anthelmintics or antihelminthics are drugs that expel parasitic worms from the body, by either stunning or killing them. They may also be called vermifuges or vermicides .-Pharmaceutical classes:...
. It has typically been used human and animal use as a standard treatment for intestinal worms.
Oxantel is currently being experimented with for the treatment of periodontal disease by the Cooperative Research Centre for Oral Health Science (CRC). Professor Eric Reynolds (also the head of Dental School at the University of Melbourne, Australia) and his Associate Professor Stuart Dashper are currently testing its ability as a Fumarate reductase
Fumarate reductase
Fumarate reductase is the enzyme that converts fumarate to succinate, and is important in microbial metabolism as a part of anaerobic respiration.Succinate + acceptor fumarate + reduced acceptor...
inhibitor.
Fumarate reductase
Fumarate reductase
Fumarate reductase is the enzyme that converts fumarate to succinate, and is important in microbial metabolism as a part of anaerobic respiration.Succinate + acceptor fumarate + reduced acceptor...
is an enzyme that has been found in the pathogenic bacteria in the biofilm in periodontal pockets. This bacteria has the ability to convert blood components into energy and for the bacteria to be virulent. Such bacteria would starve without this enzyme. As such, the role of the Oxantel as a fumarate reductase inhibitor would be to kill the bacteria responsible for periodontal disease.