Nucleoside-specific porin
Encyclopedia
Nucleoside-specific porin (the tsx gene of Escherichia coli
Escherichia coli
Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...

) is an outer membrane protein, Tsx, which constitutes the receptor for colicin
Colicin
A colicin is a type of bacteriocin produced by and toxic to some strains of Escherichia coli. Colicins are released into the environment to reduce competition from other bacterial strains...

 K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides name="PUB00006257">. The protein contains 294 amino acids, the first 22 of which are characteristic of a bacterial signal sequence peptide. Tsx shows no significant similarities to general bacterial porins
General bacterial porin family
General bacterial porins are a family of proteins from the outer membrane of Gram-negative bacteria. The porins act as molecular filters for hydrophilic compounds. They are responsible for the 'molecular sieve' properties of the outer membrane. Porins form large water-filled channels which allow...

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