Norbolethone
Encyclopedia
Norbolethone is an anabolic steroid
. It was first developed in 1966 by Wyeth
Laboratories, and tested for use as an agent to encourage weight gain and for the treatment of short stature, but was never marketed commercially because of fears that it might be toxic. It subsequently showed up in urine tests on athletes in competition in the early 2000s.
Norbolethone was found to have been brought to the market by the chemist Patrick Arnold
, of the Bay Area Laboratory Co-operative
(BALCO), an American nutritional supplement company. It is reputed to have been the active ingredient in the original formulation of the "undetectable" steroid formulation known as "The Clear" before being replaced by the more potent drug tetrahydrogestrinone
.
In 2002, Don Catlin
, MD, the founder and then-director of the UCLA Olympic Analytical Lab, identified norbolethone for the first time in an athlete’s urine sample. In the same year, U.S. bicycle racer Tammy Thomas was caught using it and was banned from her sport. The following year, Catlin identified and developed a test for tetrahydrogestrinone
or THG, the second reported designer anabolic sample—a key development in the BALCO Affair.
Anabolic steroid
Anabolic steroids, technically known as anabolic-androgen steroids or colloquially simply as "steroids", are drugs that mimic the effects of testosterone and dihydrotestosterone in the body. They increase protein synthesis within cells, which results in the buildup of cellular tissue ,...
. It was first developed in 1966 by Wyeth
Wyeth
Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA...
Laboratories, and tested for use as an agent to encourage weight gain and for the treatment of short stature, but was never marketed commercially because of fears that it might be toxic. It subsequently showed up in urine tests on athletes in competition in the early 2000s.
Norbolethone was found to have been brought to the market by the chemist Patrick Arnold
Patrick Arnold
Patrick Arnold is an American organic chemist responsible for creating the designer steroid tetrahydrogestrinone, also known as THG and "the clear". THG, along with two other anabolic steroids that Patrick Arnold manufactured , were drugs at the heart of the BALCO scandal...
, of the Bay Area Laboratory Co-operative
Bay Area Laboratory Co-operative
The Bay Area Laboratory Co-Operative was an American company led by founder and owner Victor Conte, a former bass player for the soul band Tower of Power. In 2003, journalists Lance Williams and Mark Fainaru-Wada investigated the company's role in a drug sports scandal later referred to as the...
(BALCO), an American nutritional supplement company. It is reputed to have been the active ingredient in the original formulation of the "undetectable" steroid formulation known as "The Clear" before being replaced by the more potent drug tetrahydrogestrinone
Tetrahydrogestrinone
Tetrahydrogestrinone is an anabolic steroid developed by Patrick Arnold. It has affinity to the androgen receptor and the progesterone receptor, but not to the estrogen receptor...
.
In 2002, Don Catlin
Don Catlin
Don H. Catlin, M.D. is an anti-doping scientist and one of the founders of modern drug-testing in sport. -Career:Catlin has overseen testing for performance-enhancing drugs at the three most recent Olympics held in the United States since the 1984 Summer Games in Los Angeles, as well as testing...
, MD, the founder and then-director of the UCLA Olympic Analytical Lab, identified norbolethone for the first time in an athlete’s urine sample. In the same year, U.S. bicycle racer Tammy Thomas was caught using it and was banned from her sport. The following year, Catlin identified and developed a test for tetrahydrogestrinone
Tetrahydrogestrinone
Tetrahydrogestrinone is an anabolic steroid developed by Patrick Arnold. It has affinity to the androgen receptor and the progesterone receptor, but not to the estrogen receptor...
or THG, the second reported designer anabolic sample—a key development in the BALCO Affair.