Neonatal cholestasis
Encyclopedia
Neonatal cholestasis
defines persisiting conjugated hyperbilirubinemia in the newborn with conjugated bilirubin
levels exceeding 15% (5,0 mg/dL) of total bilirubin level. The disease is either due to defects in bile
excretion from hepatocytes or impaired bile flow.
The incidence has been found to be about 1:2500 live birth
s.
Cholestasis
In medicine, cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic distinctions are an obstructive type of cholestasis where there is a mechanical blockage in the duct system such as can occur from a gallstone or malignancy and metabolic types of...
defines persisiting conjugated hyperbilirubinemia in the newborn with conjugated bilirubin
Bilirubin
Bilirubin is the yellow breakdown product of normal heme catabolism. Heme is found in hemoglobin, a principal component of red blood cells. Bilirubin is excreted in bile and urine, and elevated levels may indicate certain diseases...
levels exceeding 15% (5,0 mg/dL) of total bilirubin level. The disease is either due to defects in bile
Bile
Bile or gall is a bitter-tasting, dark green to yellowish brown fluid, produced by the liver of most vertebrates, that aids the process of digestion of lipids in the small intestine. In many species, bile is stored in the gallbladder and upon eating is discharged into the duodenum...
excretion from hepatocytes or impaired bile flow.
The incidence has been found to be about 1:2500 live birth
Birth
Birth is the act or process of bearing or bringing forth offspring. The offspring is brought forth from the mother. The time of human birth is defined as the time at which the fetus comes out of the mother's womb into the world...
s.