Neil Kelleher (scientist)
Encyclopedia
Neil L. Kelleher is a professor of chemistry
at Northwestern University
. His research focuses on mass spectrometry
, primarily its application to proteomics
. He is known mainly for top-down proteomics
and the development of the fragmentation
technique of electron-capture dissociation with Roman Zubarev
while in Fred McLafferty
's lab at Cornell University
.
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
at Northwestern University
Northwestern University
Northwestern University is a private research university in Evanston and Chicago, Illinois, USA. Northwestern has eleven undergraduate, graduate, and professional schools offering 124 undergraduate degrees and 145 graduate and professional degrees....
. His research focuses on mass spectrometry
Mass spectrometry
Mass spectrometry is an analytical technique that measures the mass-to-charge ratio of charged particles.It is used for determining masses of particles, for determining the elemental composition of a sample or molecule, and for elucidating the chemical structures of molecules, such as peptides and...
, primarily its application to proteomics
Proteomics
Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term "proteomics" was first coined in 1997 to make an analogy with...
. He is known mainly for top-down proteomics
Top-down proteomics
Top-down proteomics is a method of protein identification that uses an ion trapping mass spectrometer to store an isolated protein ion for mass measurement and tandem mass spectrometry analysis. The name is derived from the similar approach to DNA seqencing...
and the development of the fragmentation
Fragmentation (chemistry)
Fragmentation is a type of chemical dissociation. Fragmentation of a molecule can take place by a process of heterolysis or homolysis.It is a phenomenon observed in mass spectrometry where it is used as a tool to find the structural formula of a molecule, process called structural elucidation.It...
technique of electron-capture dissociation with Roman Zubarev
Roman Zubarev
Roman A. Zubarev is a professor of medical proteomics in the Department of Medical Biochemistry and Biophysics at the Karolinska Institutet. His research focuses on mass spectrometry...
while in Fred McLafferty
Fred McLafferty
Fred Warren McLafferty is an American chemist known for his work in mass spectrometry. He is best known for the McLafferty rearrangement reaction that was observed with mass spectrometry. WIth Roland Gohlke, he pioneered the technique of gas chromatography-mass spectrometry...
's lab at Cornell University
Cornell University
Cornell University is an Ivy League university located in Ithaca, New York, United States. It is a private land-grant university, receiving annual funding from the State of New York for certain educational missions...
.
Early life and education
- B.S. Pacific Lutheran UniversityPacific Lutheran UniversityPacific Lutheran University is located in Parkland, a suburb of Tacoma, Washington. In September 2009, PLU had a student population of 3,582 and approximately 280 full-time faculty...
- M.S. and Ph.D. Cornell UniversityCornell UniversityCornell University is an Ivy League university located in Ithaca, New York, United States. It is a private land-grant university, receiving annual funding from the State of New York for certain educational missions...
Research interests
- Mass spectrometryMass spectrometryMass spectrometry is an analytical technique that measures the mass-to-charge ratio of charged particles.It is used for determining masses of particles, for determining the elemental composition of a sample or molecule, and for elucidating the chemical structures of molecules, such as peptides and...
- Electron-capture dissociation
- ProteomicsProteomicsProteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term "proteomics" was first coined in 1997 to make an analogy with...
- Top-down proteomicsTop-down proteomicsTop-down proteomics is a method of protein identification that uses an ion trapping mass spectrometer to store an isolated protein ion for mass measurement and tandem mass spectrometry analysis. The name is derived from the similar approach to DNA seqencing...
- Top-down proteomics
Awards
- University Scholar, 2009–2010
- Biemann Medal, 2009
- Pittsburgh Conference Achievement Award, 2008
- Pfizer Award in Enzyme Chemistry from the ACS Division of Biological Chemistry, 2007
- Presidential Early Career Award
- Alfred P. Sloan Fellow
- Packard Fellow
- NSF CAREER Award
- Lilly Analytical Chemistry Award
- Burroughs Wellcome Fund Young Investigator
- Searle Scholar
- Fulbright Scholar
External links
- Kelleher Group
- Neil Kelleher (Northwestern University Interdepartmental Biological Sciences Program (IBiS))