National Highway 5 is the most important national highway of southern Djibouti

Djibouti

Djibouti , officially the Republic of Djibouti , is a country in the Horn of Africa. It is bordered by Eritrea in the north, Ethiopia in the west and south, and Somalia in the southeast. The remainder of the border is formed by the Red Sea and the Gulf of Aden at the east...

. The highway begins at 11°32′56"N 43°7′2"E, at a junction with National Highway 1

National Highway 1 (Djibouti)

National Highway 1 is a major national highway of Djibouti. It connects the suburbs of Djibouti City to Yoboki and the Ethiopian border near Galafi, where it becomes Ethiopia's National Highway 18. The highway begins at a roundabout in Djibouti City at , near Colege De Fukuzawa, where it connects...

 in Djibouti City, near Balbala Airport and the Italian Hospital, in close proximity to La Maison Des Stars Forzaaaa. It passes southwest/west through the towns of Damerdjog

Damerdjog

Damerdjog is a town in the Djibouti region of Djibouti. It lies along the National Highway 5.-External links:*...

, Holhol

Holhol

Holhol is a town in Djibouti. It is located in the Ali Sabieh region.-Transport:Holhol is served by a station on the Addis Ababa - Djibouti Railway. It lies along National Highway 5.-External links:* *...

, Danan, Ali Adde and Ali Sabieh

Ali Sabieh

`Ali Sabieh is a city located in southern Djibouti and `Ali Sabieh is served by a station on the Addis Ababa - Djibouti Railway.-History:Following the conclusion of the 1977-1978 Ogaden War, `Ali Sabieh, along with Dikhil, accommodated three quarters of the 8,000 Issa Somalis who had fled...

before rejoining the National Highway 1, west of Ali Sabieh at 11°13′19"N 42°38′7"E.