NNK
Encyclopedia
Nicotine-derived nitrosamine ketone (NNK), or 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone, is a nitrosamine
present in tobacco
that is a potent procarcinogen. It is activated by CYP2A6
. It is a biomarker of exposure to cigarette smoke. It is produced upon the curing of tobacco
.
Nitrosamine
Nitrosamines are chemical compounds of the chemical structure R1N-N=O, some of which are carcinogenic.-Usages:Nitrosamines are used in manufacture of some cosmetics, pesticides, and in most rubber products. -Occurrences:...
present in tobacco
Tobacco
Tobacco is an agricultural product processed from the leaves of plants in the genus Nicotiana. It can be consumed, used as a pesticide and, in the form of nicotine tartrate, used in some medicines...
that is a potent procarcinogen. It is activated by CYP2A6
CYP2A6
Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several...
. It is a biomarker of exposure to cigarette smoke. It is produced upon the curing of tobacco
Tobacco
Tobacco is an agricultural product processed from the leaves of plants in the genus Nicotiana. It can be consumed, used as a pesticide and, in the form of nicotine tartrate, used in some medicines...
.