NME1
Encyclopedia
Nucleoside diphosphate kinase A is an enzyme
that in humans is encoded by the NME1 gene
. It is thought to be a metastasis suppressor
.
with Aurora A kinase
, NME3
, Protein SET
, RAR-related orphan receptor alpha
, TERF1
, CD29
and RAR-related orphan receptor beta
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the NME1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. It is thought to be a metastasis suppressor
Metastasis suppressor
A metastasis suppressor is a protein that acts to slow or prevent metastases from spreading in the body of an organism with cancer. Metastasis is one of the most lethal attributes of cancer. This attribute is responsible for about ninety percent of human cancer deaths...
.
Interactions
NME1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Aurora A kinase
Aurora A kinase
Aurora A kinase also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for...
, NME3
NME3
Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.-Interactions:NME3 has been shown to interact with NME1 and NME2.-Further reading:...
, Protein SET
Protein SET
Protein SET is a protein that in humans is encoded by the SET gene.-Interactions:Protein SET has been shown to interact with TAF1A, NME1, CDK5R1, Acidic leucine-rich nuclear phosphoprotein 32 family member A and KLF5.-Further reading:...
, RAR-related orphan receptor alpha
RAR-related orphan receptor alpha
RAR-related orphan receptor alpha , also known as NR1F1 is a nuclear receptor that in humans is encoded by the RORA gene.- Function :...
, TERF1
TERF1
Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene.-Interactions:TERF1 has been shown to interact with SALL1, MAPRE1, NME1, TNKS2, Ataxia telangiectasia mutated, TINF2, TNKS, PINX1 and Abl gene....
, CD29
CD29
Integrin beta-1 is a protein that in humans is encoded by the ITGB1 gene. CD29 is an integrin unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and reelin.Integrins are heterodimeric...
and RAR-related orphan receptor beta
RAR-related orphan receptor beta
RAR-related orphan receptor beta , also known as NR1F2 is a nuclear receptor that in humans is encoded by the RORB gene.- Function :...
.