NK012
Encyclopedia
NK012 is a 'nanodevice' formulation of SN-38
(an irinotecan
metabolite). NK012 is an SN-38-releasing nanodevice constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in aqueous media.
It has entered phase II clinical trials for triple-negative breast cancer and relapsed small cell lung cancer.
SN-38
SN-38 is the active metabolite of irinotecan ; it is 200 times more active than irinotecan itself.SN38 is metabolized via glucoronidation by UGT1A1....
(an irinotecan
Irinotecan
Irinotecan is a drug used for the treatment of cancer.Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin....
metabolite). NK012 is an SN-38-releasing nanodevice constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in aqueous media.
It has entered phase II clinical trials for triple-negative breast cancer and relapsed small cell lung cancer.