NAN-190
Encyclopedia
NAN-190 is a drug
and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor
antagonist, but a subsequent discovery showed that it also potently blocks the α2-adrenergic
receptor. The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin
receptor antagonist.
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
antagonist, but a subsequent discovery showed that it also potently blocks the α2-adrenergic
Alpha-2 adrenergic receptor
The alpha-2 adrenergic receptor is a G protein-coupled receptor associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well...
receptor. The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin
Serotonin
Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...
receptor antagonist.