N-nucleotide
Encyclopedia
N-nucleotides, or nontemplated nucleotides are believed to exist only to create diversity at V(D)J junctions (see V(D)J recombination
) during lymphocyte development . The addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase
(TdT)
V(D)J recombination
VJ recombination, also known as somatic recombination, is a mechanism of genetic recombination in the early stages of immunoglobulin and T cell receptors production of the immune system...
) during lymphocyte development . The addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase
Terminal Deoxynucleotidyl Transferase
Terminal deoxynucleotidyl transferase , also known as DNA nucleotidylexotransferase or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells...
(TdT)