N-Acetyltransferase
Encyclopedia
N-acetyltransferase is an enzyme
that catalyzes
the transfer of acetyl
groups from acetyl-CoA
to arylamines. They have wide specificity for aromatic amine
s, particularly serotonin
, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
s that encode N-acetyltransferase enzymes:
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that catalyzes
Catalysis
Catalysis is the change in rate of a chemical reaction due to the participation of a substance called a catalyst. Unlike other reagents that participate in the chemical reaction, a catalyst is not consumed by the reaction itself. A catalyst may participate in multiple chemical transformations....
the transfer of acetyl
Acetyl
In organic chemistry, acetyl is a functional group, the acyl with chemical formula COCH3. It is sometimes represented by the symbol Ac . The acetyl group contains a methyl group single-bonded to a carbonyl...
groups from acetyl-CoA
Acetyl-CoA
Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions. Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. In chemical structure, acetyl-CoA is the thioester...
to arylamines. They have wide specificity for aromatic amine
Aromatic amine
An aromatic amine is an amine with an aromatic substituent - that is -NH2, -NH- or nitrogen group attached to an aromatic hydrocarbon, whose structure usually contains one or more benzene rings. Aniline is the simplest example....
s, particularly serotonin
Serotonin
Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...
, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
Examples
The following is a list of human geneGene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
s that encode N-acetyltransferase enzymes:
| Symbol | Name |
|---|---|
| AANAT Serotonin N-acetyl transferase Serotonin N-acetyl transferase also known as arylalkylamine N-acetyltransferase or AANAT is a protein that, in humans, is encoded by the AANAT gene.-Function:... |
arylalkylamine N-acetyltransferase |
| ARD1A ARD1A N-terminal acetyltransferase complex ARD1 subunit homolog A is an enzyme that in humans is encoded by the ARD1A gene.-Further reading:... |
ARD1 homolog A, N-acetyltransferase (S. cerevisiae) |
| GNPNAT1 | glucosamine-phosphate N-acetyltransferase 1 |
| HGSNAT HGSNAT Heparan-alpha-glucosaminide N-acetyltransferase is an enzyme that in humans is encoded by the HGSNAT gene.-External links:... |
heparan-alpha-glucosaminide N-acetyltransferase |
| MAK10 | MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae) |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
| NAT2 N-acetyltransferase 2 N-acetyltransferase 2 , also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.- Function :... |
N-acetyltransferase 2 (arylamine N-acetyltransferase) |
| NAT5 NAT5 N-terminal acetyltransferase B complex catalytic subunit NAT5 is an enzyme that in humans is encoded by the NAT5 gene.-Further reading:... |
N-acetyltransferase 5 (GCN5-related, putative) |
| NAT6 | N-acetyltransferase 6 (GCN5-related) |
| NAT8 NAT8 N-acetyltransferase 8 is a protein that in humans is encoded by the NAT8 gene.... |
N-acetyltransferase 8 (GCN5-related, putative) |
| NAT8L | N-acetyltransferase 8-like (GCN5-related, putative) |
| NAT9 NAT9 N-acetyltransferase 9 is an enzyme that in humans is encoded by the NAT9 gene.-Further reading:... |
N-acetyltransferase 9 (GCN5-related, putative) |
| NAT10 NAT10 N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene.-Further reading:... |
N-acetyltransferase 10 (GCN5-related) |
| NAT11 | N-acetyltransferase 11 (GCN5-related, putative) |
| NAT12 | N-acetyltransferase 12 (GCN5-related, putative) |
| NAT13 | N-acetyltransferase 13 (GCN5-related) |
| NAT14 | N-acetyltransferase 14 (GCN5-related, putative) |
| NAT15 | N-acetyltransferase 15 (GCN5-related, putative) |