Müller's sign
Encyclopedia
Müller's sign is the pulsation or bobbing of the uvula
Uvula
The palatine uvula, usually referred to as simply the uvula , is the conic projection from the posterior edge of the middle of the soft palate, composed of connective tissue containing a number of racemose glands, and some muscular fibers .-Function in language:The uvula plays a role in the...

 that occurs during systole
Systole (medicine)
Systole is the contraction of the heart. Used alone, it usually means the contraction of the left ventricle.In all mammals, the heart has 4 chambers. The left and right ventricles pump together. The atria and ventricles pump in sequence...

. It can be seen in patients with severe aortic insufficiency
Aortic insufficiency
Aortic insufficiency , also known as aortic regurgitation , is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle....

. Müller's sign is caused by an increased stroke volume.

Müller's sign is named for Friedrich von Müller
Friedrich von Müller
Friedrich von Müller was a German physician remembered for describing Müller's sign. He was the son of the head of the medical department in the hospital in Augsburg. He studied natural sciences in Munich and medicine in Munich, under Carl von Voit, and Würzburg...

, a German physician.
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