Mitratapide a veterinary drug for the treatment of overweight and obese dogs sold under the brand name Yarvitan. Its mechanism of action

Mechanism of action

In pharmacology, the term mechanism of action refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect...

 involves inhibition of microsomal triglyceride transfer protein

Microsomal triglyceride transfer protein

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.Apoprotein B48 on chylomicra and Apoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.-Interactive pathway map:...

 (MTP) which is responsible for the absorption of dietary lipid

Lipid

Lipids constitute a broad group of naturally occurring molecules that include fats, waxes, sterols, fat-soluble vitamins , monoglycerides, diglycerides, triglycerides, phospholipids, and others...

s. Clinical study also suggests that mitratapide may help to reverse insulin resistance in dogs.

The drug was developed by Janssen Pharmaceutica

Janssen Pharmaceutica

Janssen Pharmaceutica is pharmaceutical company, established in Belgium in 1953 by Paul Janssen. Its headquarters are located in Beerse, in the Campine region of the province of Antwerp, Belgium. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting...

 and is chemically related to the antifungal

Antifungal

* Antifungal medication, a medication used to treat fungal infection s such as athlete's foot , ringworm, candidiasis, etc.* Antifungal protein, a protein family* an adjective referring to a fungicide compound...

 drugs such as itraconazole

Itraconazole

Itraconazole , invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections. The drug may be given orally or intravenously.-Medical uses:...

which were also developed by Janssen.