Missouri State Highway 51
Encyclopedia
Route 51 is a highway in southeastern Missouri
Missouri
Missouri is a US state located in the Midwestern United States, bordered by Iowa, Illinois, Kentucky, Tennessee, Arkansas, Oklahoma, Kansas and Nebraska. With a 2010 population of 5,988,927, Missouri is the 18th most populous state in the nation and the fifth most populous in the Midwest. It...

. Its northern terminus is the Illinois
Illinois
Illinois is the fifth-most populous state of the United States of America, and is often noted for being a microcosm of the entire country. With Chicago in the northeast, small industrial cities and great agricultural productivity in central and northern Illinois, and natural resources like coal,...

 state line near Chester, Illinois
Chester, Illinois
Chester is a city located on the bluffs of the Mississippi River Valley in Randolph County, Illinois, United States. The population was 8,400 at the 2000 census. It is the county seat of Randolph County and is located south of St. Louis, Missouri.-History:...

; its southern terminus is at the Arkansas
Arkansas
Arkansas is a state located in the southern region of the United States. Its name is an Algonquian name of the Quapaw Indians. Arkansas shares borders with six states , and its eastern border is largely defined by the Mississippi River...

 state line northwest of Piggott, Arkansas
Piggott, Arkansas
Piggott, Arkansas is a city in Clay County, Arkansas, one of that county's two seats . It is also the northern terminus of the Arkansas segment of Crowley's Ridge Parkway. As of the 2000 census, Piggott's population was 3,894. The town was founded by William N...

. It continues into Illinois as Illinois Route 150
Illinois Route 150
Illinois Route 150 is an east–west state road in southern Illinois. It runs from the Chester Bridge, a truss bridge over the Mississippi River to Route 51 in the state of Missouri, to Illinois Route 154 in rural Perry County well west of Pinckneyville...

 and it continues into Arkansas as Highway 139.

Route 51 is one of the original 1922 state highways and ran from the Mississippi River
Mississippi River
The Mississippi River is the largest river system in North America. Flowing entirely in the United States, this river rises in western Minnesota and meanders slowly southwards for to the Mississippi River Delta at the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains...

 to Advance
Advance, Missouri
Advance is a small, fourth-class city located at the intersection of State Highway 25 and State Highway 91/Route C in northern Stoddard County, Missouri in the United States. As of the 2000 U.S. Census, the city's population was 1,244; a July 2007 estimate, however, showed the population to be 1,221...

.

Route 51A, a branch route, formerly connected Route 51 with Puxico when Route 51 ended at Advance (at Route 25). Route 51A would become part of the main highway when it was re-routed and extended.
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