By 1659 Piro Indians had begun settling in the area of Paso del Norte. The Mission Nuestra Señora de Guadalupe was established by Fray García for them. This mission became the southern most of the New Mexico

New Mexico

New Mexico is a state located in the southwest and western regions of the United States. New Mexico is also usually considered one of the Mountain States. With a population density of 16 per square mile, New Mexico is the sixth-most sparsely inhabited U.S...

 chain of missions along El Camino Real from Mexico City

Mexico City

Mexico City is the Federal District , capital of Mexico and seat of the federal powers of the Mexican Union. It is a federal entity within Mexico which is not part of any one of the 31 Mexican states but belongs to the federation as a whole...

 to Santa Fe

Santa Fe, New Mexico

Santa Fe is the capital of the U.S. state of New Mexico. It is the fourth-largest city in the state and is the seat of . Santa Fe had a population of 67,947 in the 2010 census...

. The original structure forms a side chapel for the Cathedral of Juarez. The Piro settlement formed the core nucleus of the original Ciudad del El Paso del Norte, which later became La Ciudad de Benito Juárez and is in the present day state of Chihuahua.