Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H₁ receptor. However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic

Anticholinergic

An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicycloverine, and the classic example is atropine....

properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms. It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings and nettle rash.