Menotropin is an active substance for the treatment of fertility disturbances. It consists of gonadotropin
Gonadotropins are protein hormones secreted by gonadotrope cells of the pituitary gland of vertebrates. This is a family of proteins, which include the mammalian hormones follitropin , lutropin , placental chorionic gonadotropins hCG and eCG and chorionic gonadotropin , as well as at least two...

s that are extracted from the urine of postmenopausal women, usually luteinizing hormone
Luteinizing hormone
Luteinizing hormone is a hormone produced by the anterior pituitary gland. In females, an acute rise of LH called the LH surge triggers ovulation and development of the corpus luteum. In males, where LH had also been called interstitial cell-stimulating hormone , it stimulates Leydig cell...

 (LH) and follicle-stimulating hormone
Follicle-stimulating hormone
Follicle-stimulating hormone is a hormone found in humans and other animals. It is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and Luteinizing hormone act...

 (FSH). Often, it contains human chorionic gonadotropin
Human chorionic gonadotropin
Human chorionic gonadotropin or human chorionic gonadotrophin is a glycoprotein hormone produced during pregnancy that is made by the developing embryo after conception and later by the syncytiotrophoblast .. Some tumors make this hormone; measured elevated levels when the patient is not...

 (hCG) as well.

Menotropin medications include Menopur, Menogon, Repronex
Repronex is a fertility medication that is injected either subcutaneously or intramuscularly. It contains follicle stimulating hormone and luteinizing hormone purified from the urine of postmenopausal women....

, Pergonal and HMG
HMG may refer to:* Heavy machine gun* Her Majesty's Government is the formal title for the British Government. If a the monarch is a king, the title changes to "His Majesty's Government"...

HMG (Human Menopausal Gonadotropin) is used for stimulating hormones by triggering FSH and LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making them more fertile.

Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to demonstrate irrefutably infectivity following intracerebral inoculation with urine from TSE-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.

The Practice Committee of the American Society for Reproductive Medicine reported: “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”

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