Membrane-bound transcription factor peptidase, site 2
Encyclopedia
Membrane-bound transcription factor peptidase, site 2 also known as Site-2 Protease (S2P) is an enzyme
encoded by the gene
which liberates the N-terminal fragment of sterol regulatory element binding protein
(SREBP) transcription factor
s from membranes . S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
encoded by the gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
which liberates the N-terminal fragment of sterol regulatory element binding protein
Sterol regulatory element binding protein
Sterol Regulatory Element-Binding Proteins are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors...
(SREBP) transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s from membranes . S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases
Intramembrane protease
Intramembrane proteases are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins. All known intramembrane proteases are themselves integral membrane proteins with multiple transmembrane domains, and they have their active sites buried within the lipid...
.