Maytansinoid
Encyclopedia
A maytansinoid is a chemical derivative of maytansine
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Some are being investigated as the cytotoxic component of antibody-drug conjugate
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Examples:
Maytansine
Maytansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus....
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Some are being investigated as the cytotoxic component of antibody-drug conjugate
Antibody-drug conjugate
Antibody-drug conjugates are a new type of targeted therapy, used for example for cancer. They consist of an antibody linked to a payload drug . Hence, they are a type of immunoconjugate and often an immunotoxin.The antibody causes the ADC to bind to the target cancer cells...
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Examples:
- Ansamitocin
- MertansineMertansineMertansine is a cytotoxic agent also known as DM1. It is a maytansinoid .Its patent rights are owned by ImmunoGen Inc.- Uses :...