• "Mainliner", a person who takes drugs intravenously
• "Mainliner", a person of the Mainline (Protestant)
• "Mainliner", a person who lives on the Pennsylvania Main Line
  Pennsylvania Main Line
  The Main Line is an unofficial historical and socio-cultural region of suburban Philadelphia, Pennsylvania, comprising a collection of affluent towns built along the old Main Line of the Pennsylvania Railroad which ran northwest from downtown Philadelphia parallel to Lancaster Avenue , a road...
  
   section of the Philadelphia suburbs
• "Mainliner", a generic name given to aircraft which flew the Mainline (flight)
  Mainline (flight)
  A mainline flight is a flight operated by an airline's main operating unit, rather than by regional alliances, regional code-shares or regional subsidiaries...
  
   routes
• "Mainliner", a specific prefix name given to a number of aircraft operated by United Airlines and possibly others (ex. Mainliner New York, Mainliner Washington, etc.)

In music

• "Mainliner", a member of The Bryn Mawr Mainliners
  Bryn Mawr Mainliners
  The Bryn Mawr Mainliners is a men's a cappella chorus, based in Bryn Mawr, Pennsylvania. Chartered in 1963 as an official chapter of the Barbershop Harmony Society, the chorus is rich in both history and accomplishment.-History:...
  
   Men's Barbershop Chorus
• "Mainliner", a member of Big Tom and The Mainliners
  Big Tom and The Mainliners
  Big Tom and The Mainliners are a Country and Irish Showband from the Castleblayney area of County Monaghan, Ireland.-1966-1975:Originally named as "The Mighty Mainliners Showband", the band achieved fame after appearing on RTÉ Television's Showband Show broadcast on 21 May 1966 performing Gentle...
  
  , an Irish country music band
• Mainliner: Wreckage from the Past
  Mainliner: Wreckage From the Past
  Mainliner: Wreckage From the Past is a collection of early recordings by Social Distortion. It was released on July 18, 1995, and contains songs which were recorded in 1981. It is a collection of singles and B-sides that had never appeared on any of the band's full-length albums...
  
  , a compilation album from the group Social Distortion
  Social Distortion
  Social Distortion is an American punk rock band formed in 1978 in Fullerton, California. The band currently consists of Mike Ness , Jonny Wickersham , Brent Harding and David Hidalgo, Jr...
  
  
• "Mainliner", is a the name of one of the groups formed by Japanese underground musician Asahito Nanjo
  Asahito Nanjo
  Asahito Nanjo is a Japanese underground musician, best known for his psychedelic rock groups High Rise, Mainliner and Musica Transonic, and the ethnic improvisation unit Toho Sara...
  
  
• "Mainliner" is the name of a song by the grindcore
  Grindcore
  Grindcore is an extreme genre of music that started in the early- to mid-1980s. It draws inspiration from some of the most abrasive music genres – including death metal, industrial music, noise and the more extreme varieties of hardcore punk....
  
   group Brutal Truth
  Brutal Truth
  Brutal Truth is an American grindcore band from New York City, formed by ex-Anthrax, Nuclear Assault, and Stormtroopers Of Death bass guitarist Dan Lilker in 1990. The group disbanded in 1999, but reformed in 2006 and continue to release new music.-History:...
  
   from their 1994 album Need to control
  Need to Control
  Need to Control is an album by grindcore band Brutal Truth. It was released on CD, cassette, and LP. A box set was also released, containing 5 records: one 5", one 6", one 7", one 8", and one 9". This box set, as well as the Japanese CD, contains four bonus tracks...
  
  .