Mad hatter disease
Encyclopedia
Mad hatter disease describes the symptoms of mercury poisoning
Mercury poisoning
Mercury poisoning is a disease caused by exposure to mercury or its compounds. Mercury is a heavy metal occurring in several forms, all of which can produce toxic effects in high enough doses...

, specifically its effect on the nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...

. These include paraesthesias, vision and hearing impairment, slurred speech, anxiety, hallucinations, irritability, depression, lack of coordination, and tremors. The condition was observed among workers in the hat-making industry in the 19th century. Chronic mercury
Mercury (element)
Mercury is a chemical element with the symbol Hg and atomic number 80. It is also known as quicksilver or hydrargyrum...

 exposure was common in hatter
Hatter
A hatter is a person engaged in hatmaking.Hatter also may refer to:*The Hatter, a fictional character in Alice's Adventures in Wonderland* Luton Town F.C., team a.k.a. "The Hatters"* Stockport County F.C., team a.k.a. "The Hatters"...

s who used a mercury solution during the process of curing animal pelts. Poor ventilation in the workshops of the time resulted in the hatters breathing in the fumes of this highly toxic metal, leading to an accumulation of mercury in the workers' bodies. Metal toxicity was poorly understood and the broad range of symptoms were also associated with insanity
Insanity
Insanity, craziness or madness is a spectrum of behaviors characterized by certain abnormal mental or behavioral patterns. Insanity may manifest as violations of societal norms, including becoming a danger to themselves and others, though not all such acts are considered insanity...

.

The phrase mad as a hatter
Mad as a hatter
"Mad as a hatter" is a colloquial phrase used in conversation to refer to a crazy person. In 18th and 19th century England mercury was used in the production of felt, which was used in the manufacturing of hats common of the time...

may have been derived from the condition, and is commonly associated with Lewis Carroll
Lewis Carroll
Charles Lutwidge Dodgson , better known by the pseudonym Lewis Carroll , was an English author, mathematician, logician, Anglican deacon and photographer. His most famous writings are Alice's Adventures in Wonderland and its sequel Through the Looking-Glass, as well as the poems "The Hunting of the...

's character the Mad Hatter
Mad Hatter
Hatta, the Hatter is a fictional character in Lewis Carroll's Alice's Adventures in Wonderland and the story's sequel, Through the Looking-Glass. He is often referred to as the Mad Hatter, though this term was never used by Carroll...

 in Alice's Adventures in Wonderland
Alice's Adventures in Wonderland
Alice's Adventures in Wonderland is an 1865 novel written by English author Charles Lutwidge Dodgson under the pseudonym Lewis Carroll. It tells of a girl named Alice who falls down a rabbit hole into a fantasy world populated by peculiar, anthropomorphic creatures...

. While the character's eccentricities differ from those suffering from mercury poisoning (the Hatter was likely inspired by Theophilus Carter
Theophilus Carter
Theophilus Carter was an eccentric British inventor and furniture dealer most famous for his combination of an alarm clock and a bed, and thought to be an inspiration for the illustration by Sir John Tenniel of Lewis Carroll's characters the Mad Hatter in Alice's Adventures in Wonderland and Hatta...

, a furniture dealer), Lewis Carroll grew up near the town of Stockport
Stockport
Stockport is a town in Greater Manchester, England. It lies on elevated ground southeast of Manchester city centre, at the point where the rivers Goyt and Tame join and create the River Mersey. Stockport is the largest settlement in the metropolitan borough of the same name...

, where hatting was the dominant trade.
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