Macrocin
Encyclopedia
Macrocin is a macrolide
antibiotic
. Biosynthetically, it is produced from demethylmacrocin by demethylmacrocin O-methyltransferase
and is converted to tylosin
, an antibiotic used in veterinary medicine, by macrocin O-methyltransferase
.
Macrolide
The macrolides are a group of drugs whose activity stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered...
antibiotic
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
. Biosynthetically, it is produced from demethylmacrocin by demethylmacrocin O-methyltransferase
Demethylmacrocin O-methyltransferase
In enzymology, a demethylmacrocin O-methyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are S-adenosyl methionine and demethylmacrocin, whereas its two products are S-adenosylhomocysteine and macrocin....
and is converted to tylosin
Tylosin
Tylosin is a macrolide-class antibiotic used in veterinary medicine. It has a broad spectrum of activity against gram positive organisms and a limited range of gram negative organisms...
, an antibiotic used in veterinary medicine, by macrocin O-methyltransferase
Macrocin O-methyltransferase
In enzymology, a macrocin O-methyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are S-adenosyl methionine and macrocin, whereas its two products are S-adenosylhomocysteine and tylosin....
.