MYH9
Encyclopedia
Myosin, heavy chain 9, non-muscle is a protein
which in humans is encoded by the MYH9 gene
.
and non-diabetic end stage renal disease in African Americans and in Hispanic Americans, though it was later shown that two independent variants in the nearby APOL1
gene were responsible for the increased risk of disease.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the MYH9 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Clinical significance
MYH9 polymorphisms have been shown to associate with glomerulosclerosisGlomerulosclerosis
Glomerulosclerosis refers to a hardening of the glomerulus in the kidney. It is a general term to describe scarring of the kidneys' tiny blood vessels, the glomeruli, the functional units in the kidney that filter urine from the blood....
and non-diabetic end stage renal disease in African Americans and in Hispanic Americans, though it was later shown that two independent variants in the nearby APOL1
APOL1
APOL1 is the gene, which in humans encodes the Apolipoprotein L1 protein.APOL1 is the gene, which in humans encodes the Apolipoprotein L1 protein....
gene were responsible for the increased risk of disease.