Myb proto-oncogene protein also known as transcriptional activator Myb is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the MYB gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

s. The protein contains three domains, an N-terminal DNA-binding domain

DNA-binding domain

A DNA-binding domain is an independently folded protein domain that contains at least one motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence or have a general affinity to DNA...

, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression

Repression

Repression may refer to:* Memory inhibition, the ability to filter irrelevant memories from attempts to recall* Political repression, the oppression or persecution of an individual or group for political reasons* Social repression...

. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis.

External links

• Drosophila Myb oncogene-like - The Interactive Fly