MDOH
Encyclopedia
3,4-Methylenedioxy-N-hydroxyamphetamine (MDOH, MDH) is an entactogen, psychedelic
, and stimulant
of the phenethylamine
and amphetamine
chemical classes. It is the N-hydroxy
homologue
of MDA, and the N-desmethyl
homologue of MDHMA. MDOH was first synthesized
and assay
ed by Alexander Shulgin
. In his book PiHKAL
(Phenethylamines i Have Known And Loved), Shulgin listed the dosage range as 100-160 mg, and the duration as approximately 3-6 hours. He describes MDOH as being very psychedelic and producing increased pleasure in beauty and nature. He also mentioned several negative side effects also seen with MDMA ("Ecstasy") such as difficulty urinating and internal dryness.
Psychedelic drug
A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics are part of a wider class of psychoactive drugs known as hallucinogens, a class that also includes related substances such as dissociatives and deliriants...
, and stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
of the phenethylamine
Substituted phenethylamine
The substituted phenethylamines are chemical compounds with the 2-phenethylamine chemical structure modified at the phenyl ring, sidechain, and/or amino group. Some of them are psychoactive drugs, including stimulants, psychedelics, opioids, and entactogens, which exert their effects primarily...
and amphetamine
Substituted amphetamine
Substituted amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions...
chemical classes. It is the N-hydroxy
Hydroxy
Hydroxy can refer to:* In chemical nomenclature, the prefix "hydroxy-" shows the presence of a hydroxyl functional group '* An abbreviation for the medication hydroxyzine, which is commonly sold under the brand names Atarax, Ucerax, Serecid, and Vistaril* Hydroxy gas: A nickname for oxyhydrogen, a...
homologue
Homology (chemistry)
In chemistry, homology refers to the appearance of homologues. A homologue is a compound belonging to a series of compounds differing from each other by a repeating unit, such as a methylene group, a peptide residue, etcetera....
of MDA, and the N-desmethyl
Desmethyl
Desmethyl is a term used in organic chemistry to refer to a methyl group that has been removed.Examples include desmethyltramadol and desmethylsertraline....
homologue of MDHMA. MDOH was first synthesized
Organic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has...
and assay
Assay
An assay is a procedure in molecular biology for testing or measuring the activity of a drug or biochemical in an organism or organic sample. A quantitative assay may also measure the amount of a substance in a sample. Bioassays and immunoassays are among the many varieties of specialized...
ed by Alexander Shulgin
Alexander Shulgin
Alexander "Sasha" Theodore Shulgin is an American pharmacologist, chemist, artist, and drug developer.Shulgin is credited with the popularization of MDMA, commonly known as ecstasy, in the late 1970s and early 1980s, especially for psychopharmaceutical use and the treatment of depression and...
. In his book PiHKAL
PiHKAL
PiHKAL: A Chemical Love Story is a book by Dr. Alexander Shulgin and Ann Shulgin which was published in 1991. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics and/or empathogen-entactogens...
(Phenethylamines i Have Known And Loved), Shulgin listed the dosage range as 100-160 mg, and the duration as approximately 3-6 hours. He describes MDOH as being very psychedelic and producing increased pleasure in beauty and nature. He also mentioned several negative side effects also seen with MDMA ("Ecstasy") such as difficulty urinating and internal dryness.