MAP1LC3A
Encyclopedia
Microtubule-associated proteins 1A/1B light chain 3A is a protein
that in humans is encoded by the MAP1LC3A gene
.
. MAPLC3A is the mammalian homologue of yeast ATG8
, an important marker and effector of autophagy
.
with Sequestosome 1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the MAP1LC3A gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
. MAPLC3A is the mammalian homologue of yeast ATG8
ATG8
Autophagy-related protein 8 is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8 to the autophagosomal membrane through a ubiquitin-like conjugation system is essential for autophagy in eukaryotes...
, an important marker and effector of autophagy
Autophagy
In cell biology, autophagy, or autophagocytosis, is a catabolic process involving the degradation of a cell's own components through the lysosomal machinery. It is a tightly regulated process that plays a normal part in cell growth, development, and homeostasis, helping to maintain a balance...
.
Interactions
MAP1LC3A has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Sequestosome 1
Sequestosome 1
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene.-Interactions:Sequestosome 1 has been shown to interact with RAD23A, TrkA, TrkB, PRKCI, RIPK1, TRAF6 and MAP1LC3A.-Further reading:...
.