Luis Colón de Toledo, 1st Duke of Veragua, 1st Duke of la Vega, 1st Marquis of Jamaica and 3rd Admiral of the Indies (Santo Domingo

Santo Domingo

Santo Domingo, known officially as Santo Domingo de Guzmán, is the capital and largest city in the Dominican Republic. Its metropolitan population was 2,084,852 in 2003, and estimated at 3,294,385 in 2010. The city is located on the Caribbean Sea, at the mouth of the Ozama River...

, 1519/1520/1522 – 29 January 1572), was the first son of Diego Colón

Diego Colón

Diego Columbus was the 2nd Admiral of the Indies, 2nd Viceroy of the Indies and 3rd Governor of the Indies. He was the firstborn son of Christopher Columbus and wife Filipa Moniz Perestrelo, and was born in 1479/1480 in Porto Santo, Portugal or 1474 in Lisbon, Portugal. He died February...

 and María de Toledo y Rojas, and grandson of Christopher Columbus

Christopher Columbus

Christopher Columbus was an explorer, colonizer, and navigator, born in the Republic of Genoa, in northwestern Italy. Under the auspices of the Catholic Monarchs of Spain, he completed four voyages across the Atlantic Ocean that led to general European awareness of the American continents in the...

.

After his father's death, a compromise was reached in 1536 in which he was named 3rd Admiral of the Indies and renounced all other rights for a perpetual annuity of 10,000 ducat

Ducat

The ducat is a gold coin that was used as a trade coin throughout Europe before World War I. Its weight is 3.4909 grams of .986 gold, which is 0.1107 troy ounce, actual gold weight...

s, the island of Jamaica

Jamaica

Jamaica is an island nation of the Greater Antilles, in length, up to in width and 10,990 square kilometres in area. It is situated in the Caribbean Sea, about south of Cuba, and west of Hispaniola, the island harbouring the nation-states Haiti and the Dominican Republic...

 as a fief, the Dukedom of Veragua  estate

Estate (house)

An estate comprises the houses and outbuildings and supporting farmland and woods that surround the gardens and grounds of a very large property, such as a country house or mansion. It is the modern term for a manor, but lacks the latter's now abolished jurisdictional authority...

 of 25 square league

League (unit)

A league is a unit of length . It was long common in Europe and Latin America, but it is no longer an official unit in any nation. The league originally referred to the distance a person or a horse could walk in an hour...

s in the Province of Veragua

Veragua

Veragua or Veraguas was the name of five territorial entities in Central America, beginning in the sixteenth century during the Spanish colonial period...

 on the Isthmus of Panama

Isthmus of Panama

The Isthmus of Panama, also historically known as the Isthmus of Darien, is the narrow strip of land that lies between the Caribbean Sea and the Pacific Ocean, linking North and South America. It contains the country of Panama and the Panama Canal...

, and the titles of 1st Duke of Veragua and 1st Marquess of Jamaica and 1st Duke of La Vega.

He married firstly in 1546 to María de Mosquera y Pasamonte, daughter of Juan de Mosquera and his wife Ofrasina de Pasamonte, and had:

• María Colón de Toledo y Mosquera, a nun in Valladolid
  Valladolid
  Valladolid is a historic city and municipality in north-central Spain, situated at the confluence of the Pisuerga and Esgueva rivers, and located within three wine-making regions: Ribera del Duero, Rueda and Cigales...
  
  
• Felipa Colón de Toledo, 2nd Duchess of Veragua

He married secondly in Valladolid, October 19, 1555 to Ana de Castro Osorio, daughter of Beatriz de Castro Osório, 6th Countess of Lemos and Sárria

Sarria

Sarria is a municipality in the province of Lugo, northwestern Spain, in the autonomous community of Galicia. Sarria is the most densely populate town on the French Way in Galicia, with 13 700 inhabitants...

, and her second husband Alvaro Osorio, without issue.