Lomustine
Encyclopedia
Lomustine(Marketed under the name CeeNU in US) is an alkylating
nitrosourea compound
used in chemotherapy
. It is in the same family as streptozotocin
. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
Cats (7,5 kg): 15mg every 6 weeks
Alkylating antineoplastic agent
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group to DNA.The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring....
nitrosourea compound
Nitrosourea compounds
Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso group and a urea.-Examples:Examples include:* Carmustine* Lomustine* Semustine* Ethylnitrosourea * Streptozotocin...
used in chemotherapy
Chemotherapy
Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen....
. It is in the same family as streptozotocin
Streptozotocin
Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals...
. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
Dose
Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC)Cats (7,5 kg): 15mg every 6 weeks