List of vaccine ingredients
Encyclopedia
This list of vaccine ingredients indicates the culture media used in the production of common vaccine
s and the excipient
s they contain:
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...
s and the excipient
Excipient
An excipient is generally a pharmacologically inactive substance used as a carrier for the active ingredients of a medication. In many cases, an "active" substance may not be easily administered and absorbed by the human body; in such cases the substance in question may be dissolved into or...
s they contain:
| Vaccine | Culture media | Excipients |
|---|---|---|
| Anthrax vaccine Anthrax vaccine Anthrax vaccines are vaccines against the infectious disease anthrax. Anthrax is caused by the spore-forming bacterium Bacillus anthracis, that most commonly occurs in wild and domestic mammals. Anthrax also occurs in humans when they are exposed to infected animals, hides, or tissue from infected... (BioThrax) |
Puziss-Wright medium 1095, synthetic or semisynthetic | Aluminum Hydroxide, Amino Acids, Benzethonium Chloride, Formaldehyde or Formalin, Inorganic Salts and Sugars, Vitamins |
| BCG (Bacillus Calmette-Guérin Bacillus Calmette-Guérin Bacillus Calmette-Guérin is a vaccine against tuberculosis that is prepared from a strain of the attenuated live bovine tuberculosis bacillus, Mycobacterium bovis, that has lost its virulence in humans by being specially subcultured in an artificial medium for 13 years, and also prepared from... ) (Tice) |
Synthetic or semisynthetic | Asparagine, Citric Acid, Lactose, Glycerin, Iron Ammonium Citrate, Magnesium Sulfate, Potassium Phosphate |
| DTaP (Daptacel) | Cohen-Wheeler or Stainer-Scholte media, synthetic or semisynthetic | Aluminum Phosphate, Ammonium Sulfate, Casamino Acid, Dimethyl-betacyclodextrin, Formaldehyde or Formalin, Glutaraldehyde, 2-Phenoxyethanol |
| DTaP (Infanrix) | Cohen-Wheeler or Stainer-Scholte media, Lathan medium derived from bovine casein, Linggoud-Fenton medium derived from bovine extract, synthetic or semisynthetic | Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldhyde, 2-Phenoxyethanol, Polysorbate 80 |
| DTaP (Tripedia) | Cohen-Wheeler or Stainer-Scholte media, synthetic or semisynthetic | Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sodium Phosphate, Thimerosal |
| DTaP/Hib (TriHIBit) | Synthetic or semisynthetic | Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sucrose, Thimerosal |
| DTaP-IPV (Kinrix) | Synthetic or semisynthetic | Aluminum Hydroxide, Bovine Extract, Formaldehyde, Lactalbumin Hydrolysate, Monkey Kidney Tissue, Neomycin Sulfate, Polymyxin B, Polysorbate 80 |
| DTaP-HepB-IPV (Pediarix) | Bovine protein, Lathan medium derived from bovine casein, Linggoud-Fenton medium derived from bovine extract, Monkey kidney tissue culture (Vero), synthetic or semisynthetic | Aluminum Hydroxide, Aluminum Phosphate, Bovine Protein, Lactalbumin Hydrolysate, Formaldehyde or Formalin, Glutaraldhyde, Monkey Kidney Tissue, Neomycin, 2-Phenoxyethanol, Polymyxin B, Polysorbate 80, Yeast Protein |
| DtaP-IPV/Hib (Pentacel) | Synthetic or semisynthetic | Aluminum Phosphate, Bovine Serum Albumin, Formaldehyde, Glutaraldhyde, MRC-5 DNA and Cellular Protein, Neomycin, Polymyxin B Sulfate, Polysorbate 80, 2-Phenoxyethanol |
| DT (diphtheria vaccine Diphtheria vaccine Diphtheria vaccine is a vaccine used against Corynebacterium diphtheriae, the agent that causes diphtheria.Several combination vaccines are used to prevent Diptheria. It is a component of the DPT vaccine.... plus tetanus vaccine Tetanus vaccine Tetanus vaccine is a vaccine used against Clostridium tetani, the agent that causes tetanus.The vaccine is composed of tetanus toxoid, tetanus toxin inactivated with formaldehyde, which is immunogenic but not pathogenic. It is a component of the DPT vaccine.The tetanus vaccine is required again... ) (Sanofi) |
Synthetic or semisynthetic | Aluminum Potassium Sulfate, Bovine Extract, Formaldehyde or Formalin, Thimerosal (multi-dose) or Thimerosal (single-dose) |
| Hib vaccine Hib vaccine Haemophilus influenzae type B vaccine is a conjugate vaccine developed for the prevention of invasive disease caused by Haemophilus influenzae type b bacteria. The Centers for Disease Control and Prevention has recommended the use of the Hib vaccine. Due to routine use of the Hib vaccine in... (ACTHib) |
Synthetic or semisynthetic | Ammonium Sulfate, Formaldehyde or Formalin, Sucrose |
| DT (Massachusetts) | Synthetic or semisynthetic | Aluminum Hydroxide, Formaldehyde or Formalin |
| Hib (PedvaxHib) | Synthetic or semisynthetic | Aluminum Hydroxyphosphate Sulfate |
| Hib/Hep B (Comvax) | Synthetic or semisynthetic, yeast or yeast extract | Amino Acids, Aluminum Hydroxyphosphate Sulfate, Dextrose, Formaldehyde or Formalin, Mineral Salts, Sodium Borate, Soy Peptone, Yeast Protein |
| Hep A (Havrix), Hepatitis A vaccine Hepatitis A vaccine Hepatitis A vaccine is a vaccine against the hepatitis A virus. The first successful vaccine against it was invented by Maurice Hilleman at Merck. The vaccine protects against the virus in more than 95% of cases and provides protection from the virus for at least ten years... |
Human diploid tissue culture, MRC-5 | Aluminum Hydroxide, Amino Acids, Formaldehyde or Formalin, MRC-5 Cellular Protein, Neomycin Sulfate, 2-Phenoxyethanol, Phosphate Buffers, Polysorbate |
| Hep A (Vaqta), Hepatitis A vaccine Hepatitis A vaccine Hepatitis A vaccine is a vaccine against the hepatitis A virus. The first successful vaccine against it was invented by Maurice Hilleman at Merck. The vaccine protects against the virus in more than 95% of cases and provides protection from the virus for at least ten years... |
Human diploid tissue culture, MRC-5 | Aluminum Hydroxyphosphate Sulfate, Bovine Albumin or Serum, DNA, Formaldehyde or Formalin, MRC-5 Cellular Protein, Sodium Borate |
| Hep B (Engerix-B), Hepatitis B vaccine Hepatitis B vaccine Hepatitis B vaccine is a vaccine developed for the prevention of hepatitis B virus infection. The vaccine contains one of the viral envelope proteins, hepatitis B surface antigen . It is produced by yeast cells, into which the genetic code for HBsAg has been inserted... |
Yeast or yeast extract | Aluminum Hydroxide, Phosphate Buffers, Thimerosal, Yeast Protein |
| Hep B (Recombivax), Hepatitis B vaccine Hepatitis B vaccine Hepatitis B vaccine is a vaccine developed for the prevention of hepatitis B virus infection. The vaccine contains one of the viral envelope proteins, hepatitis B surface antigen . It is produced by yeast cells, into which the genetic code for HBsAg has been inserted... |
Yeast or yeast extract | Aluminum Hydroxyphosphate Sulfate, Amino Acids, Dextrose, Formaldehyde or Formalin, Mineral Salts, Potassium Aluminum Sulfate, Soy Peptone, Yeast Protein |
| HepA/HepB vaccine (Twinrix) | Human diploid tissue culture (MRC-5), yeast or yeast extract | Aluminum Hydroxide, Aluminum Phosphate, Amino Acids, Dextrose, Formaldehyde or Formalin, Inorganic Salts, MRC-5 Cellular Protein, Neomycin Sulfate, 2-Phenoxyethanol, Phosphate Buffers, Polysorbate 20, TWINRIX does not contain Thimerosal |
| Human Papillomavirus (HPV) (Gardasil Gardasil Gardasil , also known as Gardisil or Silgard, is a vaccine for use in the prevention of certain types of human papillomavirus , specifically HPV types 6, 11, 16 and 18. HPV types 16 and 18 cause an estimated 70% of cervical cancers, and are responsible for most HPV-induced anal, vulvar, vaginal,... ) |
Yeast or yeast extract | Amino Acids, Amorphous Aluminum Hydroxyphosphate Sulfate, Carbohydrates, L-histidine, Mineral Salts, Polysorbate 80, Sodium Borate, Vitamins |
| Influenza vaccine (Afluria) | Chicken embryo | Beta-Propiolactone, Calcium Chloride, Neomycin, Ovalbumin, Polymyxin B, Potassium Chloride, Potassium Phosphate, Sodium Phosphate, Sodium Taurodeoxychoalate. |
| Influenza vaccine (Fluarix) | Chicken embryo | Egg Albumin (Ovalbumin), Egg Protein, Formaldehyde or Formalin, Gentamicin, Hydrocortisone, Octoxynol-10, á-Tocopheryl Hydrogen Succinate, Polysorbate 80, Sodium Deoxycholate, Sodium Phosphate, Thimerosal |
| Influenza vaccine (Flulaval) | Chicken embryo | Egg Albumin (Ovalbumin), Egg Protein, Formaldehyde or Formalin, Sodium Deoxycholate, Phosphate Buffers, Thimerosal |
| Influenza vaccine (Fluvirin) | Chicken embryo | Beta-Propiolactone , Egg Protein, Neomycin, Polymyxin B, Polyoxyethylene 9- 10 Nonyl Phenol (Triton N-101, Octoxynol 9), Thimerosal (multidose containers), Thimerosal (single-dose syringes) |
| Influenza vaccine (Fluzone) | Chicken embryo | Egg Protein, Formaldehyde or Formalin, Gelatin, Octoxinol-9 (Triton X-100), Thimerosal (multidose containers) |
| Influenza vaccine (FluMist) | Chicken kidney cells, chicken embryo | Chick Kidney Cells, Egg Protein, Gentamicin Sulfate, Monosodium Glutamate, Sucrose Phosphate Glutamate Buffer |
| IPV (Ipol), Polio vaccine Polio vaccine Two polio vaccines are used throughout the world to combat poliomyelitis . The first was developed by Jonas Salk and first tested in 1952. Announced to the world by Salk on April 12, 1955, it consists of an injected dose of inactivated poliovirus. An oral vaccine was developed by Albert Sabin... |
Monkey kidney tissue culture (Vero cell) | Calf Serum Protein, Formaldehyde or Formalin, Monkey Kidney Tissue, Neomycin, 2-Phenoxyethanol, Polymyxin B, Streptomycin, |
| Japanese encephalitis vaccine Japanese encephalitis vaccine Japanese encephalitis vaccine is a vaccine used against Japanese encephalitis.-History:Two sorts of Japanese encephalitis vaccines became available in the 1950s. One of them was an inactivated mouse brain-derived vaccine , made by BIKEN and marketed by Sanofi Pasteur as JE-VAX, until production... (JE-Vax) |
Mouse brain culture | Formaldehyde or Formalin, Gelatin, Mouse Serum Protein, Polysorbate 80,Thimerosal |
| Japanese encephalitis vaccine (Ixiaro) | Aluminum Hydroxide, Bovine Serum Albumin, Formaldehyde, Protamine Sulfate, Sodium Metabisulphite |
|
| Meningococcal vaccine Meningococcal vaccine Meningococcal vaccine is a vaccine used against Meningococcus, a bacterium that causes meningitis, meningococcemia, septicemia, and rarely carditis, septic arthritis, or pneumonia.-Types:... (Menactra) |
Mueller-Miller medium, Mueller-Minton medium, Watson-Scherp medium | Formaldehyde or Formalin, Phosphate Buffers Meningococcal (Menomune) Lactose, Thimerosal (10-dose vials only) |
| MMR vaccine MMR vaccine The MMR vaccine is an immunization shot against measles, mumps, and rubella . It was first developed by Maurice Hilleman while at Merck in the late 1960s.... (MMR-II) |
Human diploid tissue culture (WI-38), Medium 199 | Amino Acid, Bovine Albumin or Serum, Chick Embryo Fibroblasts, Human Serum Albumin, Gelatin, Glutamate, Neomycin, Phosphate Buffers, Sorbitol, Sucrose, Vitamins |
| MMRV vaccine (ProQuad) | Human diploid tissue cultures (MRC-5, WI-38), Medium 199 | Bovine Albumin or Serum, Gelatin, Human Serum Albumin, Monosodium L-glutamate, MRC-5 Cellular Protein, Neomycin, Sodium Phosphate Dibasic, Sodium Bicarbonate, Sorbitol, Sucrose, Potassium Phosphate Monobasic, Potassium Chloride, Potassium Phosphate Dibasic |
| Pneumococcal vaccine Pneumococcal vaccine A pneumococcal vaccine is a vaccine against Streptococcus pneumoniae.Types include:* Pneumococcal polysaccharide vaccine* Pneumococcal conjugate vaccine-Vaccination in the USA:... (Pneumovax) |
Bovine protein | Bovine Protein, Phenol |
| Pneumococcal vaccine (Prevnar) | Soy peptone broth | Aluminum Phosphate, Amino Acid, Soy Peptone, Yeast Extract |
| Poliovirus inactivated (Poliovax), Polio vaccine Polio vaccine Two polio vaccines are used throughout the world to combat poliomyelitis . The first was developed by Jonas Salk and first tested in 1952. Announced to the world by Salk on April 12, 1955, it consists of an injected dose of inactivated poliovirus. An oral vaccine was developed by Albert Sabin... |
Human diploid tissue culture, MRC-5 | ? |
| Rabies vaccine Rabies vaccine Rabies vaccine is a vaccine used to control rabies. Rabies can be prevented by vaccination, both in humans and other animals.-In animals:Currently, pre-exposure immunization has been used on domesticated and normal non-human populations... (Imovax) |
Human dilpoid tissue culture, MRC-5 | Human Serum Albumin, Beta-Propiolactone, MRC-5 Cellular Protein, Neomycin, Phenol Red (Phenolsulfonphthalein), Vitamins |
| Rabies vaccine (RabAvert) | Rhesus fetal lung tissue culture, Chicken embryo | Amphotericin B, Beta-Propiolactone, Bovine Albumin or Serum, Chicken Protein, Chlortetracycline, Egg Albumin (Ovalbumin), Ethylenediamine- Tetraacetic Acid Sodium (EDTA), Neomycin, Potassium Glutamate |
| Rotavirus vaccine (RotaTeq) | Monkey kidney tissue culture (Vero) | Cell Culture Media, Fetal Bovine Serum, Sodium Citrate, Sodium Phosphate Monobasic Monohydrate, Sodium Hydroxide Sucrose, Polysorbate 80 |
| Rotavirus vaccine (Rotarix) | Amino Acids, Calcium Carbonate, Calcium Chloride, D-glucose, Dextran, Ferric (III) Nitrate, L-cystine, L-tyrosine, Magnesium Sulfate, Phenol Red, Potassium Chloride, Sodium Hydrogenocarbonate, Sodium Phosphate, Sodium L-glutamine, Sodium Pyruvate, Sorbitol, Sucrose, Vitamins, Xanthan |
|
| Td vaccine (Decavac) | Synthetic or semisynthetic | Aluminum Potassium Sulfate, Bovine Extract, Formaldehyde or Formalin, 2- Phenoxyethanol, Peptone, Thimerosal |
| Td vaccine (Massachusetts) | Synthetic or semisynthetic | Aluminum Hydroxide, Aluminum Phosphate, Formaldehyde or Formalin, Thimerosal (some multidose containers) |
| Tdap vaccine (Adacel) | Synthetic or semisynthetic | Aluminum Phosphate, Formaldehyde or Formalin, Glutaraldehyde, 2- Phenoxyethanol |
| Tdap vaccine (Boostrix) | Fenton media with bovine casein, Lathan medium derived from bovine casein, Linggoud-Fenton medium derived from bovine extract, synthetic or semisynthetic | Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldehyde, Polysorbate 80 |
| Typhoid (inactivated –Typhim Vi), Typhus vaccine Typhus vaccine Typhus vaccine is a vaccine used against typhus.... |
Synthetic or semisynthetic | Disodium Phosphate, Monosodium Phosphate, Phenol, Polydimethylsilozone, Hexadecyltrimethylammonium Bromide |
| Typhoid (oral – Ty21a), Typhus vaccine Typhus vaccine Typhus vaccine is a vaccine used against typhus.... |
Bovine protein | Amino Acids, Ascorbic Acid, Bovine Protein, Casein, Dextrose, Galactose, Gelatin, Lactose, Magnesium Stearate, Sucrose, Yeast Extract |
| Vaccinia Vaccinia Vaccinia virus is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, and which encodes for approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm, with a mass of... (ACAM2000 ACAM2000 ACAM2000 is a smallpox vaccine developed by . It was approved for use in the United States by the U.S. Food and Drug Administration on 31 August 2007. It contains live vaccinia virus, cloned from the same strain used in an earlier vaccine, Dryvax... ) |
Calf skin, Monkey kidney cell culture (Vero cell) | Glycerin, Human Serum Albumin, Mannitol, Monkey Kidney Cells, Neomycin, Phenol, Polymyxin B |
| Varicella vaccine Varicella vaccine The varicella vaccine is a live virus that protects against the viral disease commonly known as chickenpox caused by Varicella Zoster Virus . Varicella vaccine is marketed as Varivax in the U.S. by Merck... (Varivax) |
Human diploid tissue cultures, MRC-5 and WI-38 | Bovine Albumin or Serum, Ethylenediamine-Tetraacetic Acid Sodium (EDTA), Gelatin, Monosodium L-Glutamate, MRC-5 DNA and Cellular Protein, Neomycin, Potassium Chloride, Potassium Phosphate Monobasic, Sodium Phosphate Monobasic, Sucrose |
| Yellow fever vaccine Yellow fever vaccine Yellow fever vaccine is a vaccine used against yellow fever.The vaccine consists of a live, but attenuated, strain of the yellow fever virus called 17D. The 17D vaccine has been used commercially since the 1950s. The mechanisms of attenuation and immunogenicity for the 17D strain are not known... (YF-Vax) |
Chicken embryo | Egg Protein, Gelatin, Sorbitol |
| Zoster vaccine (Zostavax) | Human diploid tissue cultures, MRC-5, and WI-38 | Bovine Calf Serum, Hydrolyzed Porcine Gelatin, Monosodium L-glutamate, MRC-5 DNA and Cellular Protein, Neomycin, Potassium Phosphate Monobasic, Potassium Chloride, Sodium Phosphate Dibasic, Sucrose |