Lipoxygenase inhibitor
Encyclopedia
A Lipoxygenase inhibitor is a drug that slows down or stops the action of the lipoxygenase
enzyme. The term is almost always used to describe an inhibitor of the arachidonate 5-lipoxygenase
enzyme, which transforms EFAs
into leukotrienes.
Examples include:
Lipoxygenase
Lipoxygenases are a family of iron-containing enzymes that catalyse the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene structure. It catalyses the following reaction:...
enzyme. The term is almost always used to describe an inhibitor of the arachidonate 5-lipoxygenase
Arachidonate 5-lipoxygenase
Arachidonate 5-lipoxygenase also known as 5-lipoxygenase or 5-LO is an enzyme that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes...
enzyme, which transforms EFAs
Essential fatty acid
Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health but cannot synthesize them...
into leukotrienes.
Examples include:
- azelastineAzelastineAzelastine is a potent, second-generation, selective, histamine antagonist manufactured by MedaPharma. According to the Allergic Rhinitis and its Impact on Asthma treatment guidelines, intranasal anti-histamines are recommended for the first line therapy of mild intermittent, moderate/severe...
- diethylcarbamazineDiethylcarbamazineDiethylcarbamazine is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.-Uses:...
- nordihydroguaiaretic acid
- zileutonZileutonZileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes formation. Zileuton is used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the...