LCOR
Encyclopedia
Ligand-dependent corepressor is a protein
that in humans is encoded by the LCOR gene
.
widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptor
s through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the LCOR gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
LCOR is a transcriptional corepressorCorepressor (genetics)
In molecular genetics, a corepressor is a substance that inhibits the expression of genes. A corepressor downregulates the expression of genes not through direct interaction with a gene promoter , but rather indirectly through interaction with repressor proteins that in turn bind to the...
widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptor
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
s through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.