L-759,656
Encyclopedia
L-759,656 is an analgesic
drug which is a cannabinoid agonist
. It is a highly selective agonist for the CB2 receptor
, with selectivity of 414x for CB2 over CB1, although it is still not as selective as newer agents such as HU-308
.
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative
or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
drug which is a cannabinoid agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
. It is a highly selective agonist for the CB2 receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
, with selectivity of 414x for CB2 over CB1, although it is still not as selective as newer agents such as HU-308
HU-308
HU-308 is a drug which acts as a cannabinoid agonist. It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1. The synthesis and characterization took place in the laboratory of Prof. Mechoulam at the Hebrew University of Jerusalem in the late 1990s...
.
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.