Keratin 9
Encyclopedia
Keratin 9 is a protein
that in humans is encoded by the KRT9 gene
.
Keratin 9 is a type I cytokeratin
. It is found only in the terminally differentiated epidermis of palm
s and soles
. Mutations in the gene encoding this protein cause epidermolytic palmoplantar keratoderma.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the KRT9 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Keratin 9 is a type I cytokeratin
Type I cytokeratin
Type I keratins constitutes the Type I intermediate filaments of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells...
. It is found only in the terminally differentiated epidermis of palm
Hand
A hand is a prehensile, multi-fingered extremity located at the end of an arm or forelimb of primates such as humans, chimpanzees, monkeys, and lemurs...
s and soles
Sole (foot)
The sole is the bottom of the foot.In humans the sole of the foot is anatomically referred to as the plantar aspect. The equivalent surface in ungulates is the hoof.- Human sole :...
. Mutations in the gene encoding this protein cause epidermolytic palmoplantar keratoderma.