Keratin 18
Encyclopedia
Keratin 18 is a type I cytokeratin
. It is, together with its filament partner keratin 8
, perhaps the most commonly found products of the intermediate filament
gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Keratin 18 is often used together with keratin 8
and keratin 19
to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cell
s in blood.
with Collagen, type XVII, alpha 1, DNAJB6
, Pinin
and TRADD
.
Type I cytokeratin
Type I keratins constitutes the Type I intermediate filaments of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells...
. It is, together with its filament partner keratin 8
Keratin 8
Keratin, type I cytoskeletal 8 also known as cytokeratin-8 or keratin-8 is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18.-Utility as an immunohistochemical stain:...
, perhaps the most commonly found products of the intermediate filament
Intermediate filament
Intermediate filaments are a family of related proteins that share common structural and sequence features. Intermediate filaments have an average diameter of 10 nanometers, which is between that of 7 nm actin , and that of 25 nm microtubules, although they were initially designated...
gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Keratin 18 is often used together with keratin 8
Keratin 8
Keratin, type I cytoskeletal 8 also known as cytokeratin-8 or keratin-8 is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18.-Utility as an immunohistochemical stain:...
and keratin 19
Keratin 19
Keratin, type I cytoskeletal 19 also known as cytokeratin-19 or keratin-19 is a protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin.- Function :Keratin 19 is a member of the keratin family...
to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cell
Circulating Tumor Cell
Circulating tumor cells are cells that have detached from a primary tumor and circulate in the bloodstream. CTCs may constitute seeds for subsequent growth of additional tumors in different tissues....
s in blood.
Interactions
Keratin 18 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Collagen, type XVII, alpha 1, DNAJB6
DNAJB6
DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.-Interactions:DNAJB6 has been shown to interact with Keratin 18.-Further reading:...
, Pinin
Pinin
Pinin is a protein that in humans is encoded by the PNN gene.-Interactions:Pinin has been shown to interact with Keratin 8, Keratin 18, Keratin 19, CTBP1, RNPS1, PRPF4B, SFRS4, PPIG, SRRM2 and SFRS18.-Further reading:...
and TRADD
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.TRADD is an adaptor protein.- Function :...
.