Keratin 1
Encyclopedia
Keratin 1 is a member of the keratin
family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10
. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.
with Desmoplakin
and PRKCE
.
Keratin
Keratin refers to a family of fibrous structural proteins. Keratin is the key of structural material making up the outer layer of human skin. It is also the key structural component of hair and nails...
family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10
Keratin 10
Keratin, type I cytoskeletal 10 also known as cytokeratin-10 or keratin-10 is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.- Function :...
. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.
Interactions
Keratin 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Desmoplakin
Desmoplakin
Desmoplakin is a protein associated with desmosomes.Desmoplakin is a protein that in humans is encoded by the DSP gene. The C-terminus of desmoplakin binds with intermediate filaments. These are further sub divided to three homologous Plakin repeat domains . In the mid-region of desmoplakin, a...
and PRKCE
PRKCE
Protein kinase C epsilon type is an enzyme that in humans is encoded by the PRKCE gene.- Function :Protein kinase C is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol...
.