Kallidin
Encyclopedia
Kallidin is a bioactive kinin
formed in response to injury from kininogen precursors through the action of kallikrein
s.
Kallidin is a decapeptide that can be converted to bradykinin
by the aminopeptidase
enzyme.
It can be a substrate for carboxypeptidase
M and N.
Kallidin is identical to bradykinin
with an additional lysine
residue added at the N-terminal end and signals through the bradykinin receptor
.
Kinin
A kinin is any of various structurally related polypeptides, such as bradykinin and kallikrein. They are members of the autacoid family.They act locally to induce vasodilation and contraction of smooth muscle.It is a component of the kinin-kallikrein system....
formed in response to injury from kininogen precursors through the action of kallikrein
Kallikrein
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known homologue, while tissue kallikrein-related peptidases encode a family of fifteen closely related serine proteases...
s.
Kallidin is a decapeptide that can be converted to bradykinin
Bradykinin
Bradykinin is a peptide that causes blood vessels to dilate , and therefore causes blood pressure to lower. A class of drugs called ACE inhibitors, which are used to lower blood pressure, increase bradykinin further lowering blood pressure...
by the aminopeptidase
Aminopeptidase
Aminopeptidase is a zinc-dependent enzyme produced and secreted by glands of the small intestine. It helps the enzymatic digestion of proteins. Additional digestive enzymes produced by these glands include dipeptidases, maltase, sucrase, lactase, and enterokinase.Aminopeptidases catalyze the...
enzyme.
It can be a substrate for carboxypeptidase
Carboxypeptidase
A carboxypeptidase is a protease enzyme that hydrolyzes the peptide bond of an amino acid residue at the carboxy-terminal end...
M and N.
Kallidin is identical to bradykinin
Bradykinin
Bradykinin is a peptide that causes blood vessels to dilate , and therefore causes blood pressure to lower. A class of drugs called ACE inhibitors, which are used to lower blood pressure, increase bradykinin further lowering blood pressure...
with an additional lysine
Lysine
Lysine is an α-amino acid with the chemical formula HO2CCH4NH2. It is an essential amino acid, which means that the human body cannot synthesize it. Its codons are AAA and AAG....
residue added at the N-terminal end and signals through the bradykinin receptor
Bradykinin receptor
The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin.There are two Bradykinin receptors: the B1 receptor and the B2 receptor.-B1 receptor:...
.