KLF14
Encyclopedia
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein
that in humans is encoded by the KLF14 gene
. The corresponding Klf14 mouse gene is known as Sp6.
family of transcription factor
s. It regulates the transcription of various genes, including TGFβRII
(the type II receptor for TGFβ). KLF14 is expressed in many tissues, lacks introns
, and is subject to parent-specific expression.
KLF14 appears to be a master regulator of gene expression in adipose tissue
.
domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.
Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124; in the mouse its length is 325.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the KLF14 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. The corresponding Klf14 mouse gene is known as Sp6.
Function
KLF14 is a member of the Krüppel-like factorKruppel-like factors
The Krüppel-like family of transcription factors , so named for their homology to the Drosophila melanogaster Krüppel protein, have been extensively studied for their roles in cell proliferation, differentiation and survival, especially in the context of cancer . All KLF family members are...
family of transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s. It regulates the transcription of various genes, including TGFβRII
TGF beta receptors
TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric...
(the type II receptor for TGFβ). KLF14 is expressed in many tissues, lacks introns
Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing to generate the final mature RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts. Sequences that are joined together in the final...
, and is subject to parent-specific expression.
KLF14 appears to be a master regulator of gene expression in adipose tissue
Adipose tissue
In histology, adipose tissue or body fat or fat depot or just fat is loose connective tissue composed of adipocytes. It is technically composed of roughly only 80% fat; fat in its solitary state exists in the liver and muscles. Adipose tissue is derived from lipoblasts...
.
Protein structure
Like the other members of the KLF family, KLF14 has three zinc-fingerZinc finger
Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...
domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.
Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124; in the mouse its length is 325.